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CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer.

For research use only. We do not sell to patients.

CGP78850 Chemical Structure

CGP78850 Chemical Structure

CAS No. : 258326-83-9

Size Price Stock Quantity
5 mg USD 900 In-stock
10 mg USD 1420 In-stock
25 mg USD 2900 In-stock
50 mg USD 4650 In-stock
100 mg USD 7400 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

CGP78850 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer[1].

IC50 & Target

Grb2 SH2-phosphopeptide[1]
In Vitro

CGP78850 (0~100 μM; 90 minutes; MDA-MB-468 cells) reduces the amount of associated Grb2 protein in a dose-dependent manner[1].
CGP78850 blocks epidermal growth factor receptor (EGFR)-Grb2 and Shc-Grb2 interaction in living cells. CGP78850 inhibits MDA-MB-468 cells to form colonies in soft agar in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CGP78850 Related Antibodies

Western Blot Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 0~100 μM
Incubation Time: 90 minutes
Result: Reduced the amount of associated Grb2 protein in a dose-dependent manner.
Molecular Weight

723.75

Formula

C36H46N5O9P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(O)CC(C=C1)=CC=C1C[C@H](NC(C)=O)C(NC2(CCCCC2)C(N[C@@H](CC(N)=O)C(NCCCC3=C(O)C=CC4=C3C=CC=C4)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (345.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3817 mL 6.9085 mL 13.8169 mL
5 mM 0.2763 mL 1.3817 mL 2.7634 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3817 mL 6.9085 mL 13.8169 mL 34.5423 mL
5 mM 0.2763 mL 1.3817 mL 2.7634 mL 6.9085 mL
10 mM 0.1382 mL 0.6908 mL 1.3817 mL 3.4542 mL
15 mM 0.0921 mL 0.4606 mL 0.9211 mL 2.3028 mL
20 mM 0.0691 mL 0.3454 mL 0.6908 mL 1.7271 mL
25 mM 0.0553 mL 0.2763 mL 0.5527 mL 1.3817 mL
30 mM 0.0461 mL 0.2303 mL 0.4606 mL 1.1514 mL
40 mM 0.0345 mL 0.1727 mL 0.3454 mL 0.8636 mL
50 mM 0.0276 mL 0.1382 mL 0.2763 mL 0.6908 mL
60 mM 0.0230 mL 0.1151 mL 0.2303 mL 0.5757 mL
80 mM 0.0173 mL 0.0864 mL 0.1727 mL 0.4318 mL
100 mM 0.0138 mL 0.0691 mL 0.1382 mL 0.3454 mL
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CGP78850 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGP78850258326-83-9CGP 78850CGP-78850OtherspotentselectivecompetitorGrb2SH2-phosphopeptideMDA-MB-468Inhibitorinhibitorinhibit

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