2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. CGS 20625

CGS 20625 is a potent, selective and orally active partial agonist for the central benzodiazepine receptor. CGS 20625 inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors with an IC50 of 1.3 nM. CGS 20625 can be used for the research of pentylenetetrazol-induced seizures.

For research use only. We do not sell to patients.

CGS 20625 Chemical Structure

CGS 20625 Chemical Structure

CAS No. : 111205-55-1

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5 mg USD 200 In-stock
10 mg USD 320 In-stock
25 mg USD 625 In-stock
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Description

CGS 20625 is a potent, selective and orally active partial agonist for the central benzodiazepine receptor. CGS 20625 inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors with an IC50 of 1.3 nM. CGS 20625 can be used for the research of pentylenetetrazol-induced seizures[1].

IC50 & Target

IC50: 1.3 nM ([3H]-flunitrazepam binding to central benzodiazepine receptors)[1]
Molecular Weight

309.36

Formula

C18H19N3O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CNC(CCCCC3)=C3C2=NN1C4=CC=C(OC)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (161.62 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2325 mL 16.1624 mL 32.3248 mL
5 mM 0.6465 mL 3.2325 mL 6.4650 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2325 mL 16.1624 mL 32.3248 mL 80.8120 mL
5 mM 0.6465 mL 3.2325 mL 6.4650 mL 16.1624 mL
10 mM 0.3232 mL 1.6162 mL 3.2325 mL 8.0812 mL
15 mM 0.2155 mL 1.0775 mL 2.1550 mL 5.3875 mL
20 mM 0.1616 mL 0.8081 mL 1.6162 mL 4.0406 mL
25 mM 0.1293 mL 0.6465 mL 1.2930 mL 3.2325 mL
30 mM 0.1077 mL 0.5387 mL 1.0775 mL 2.6937 mL
40 mM 0.0808 mL 0.4041 mL 0.8081 mL 2.0203 mL
50 mM 0.0646 mL 0.3232 mL 0.6465 mL 1.6162 mL
60 mM 0.0539 mL 0.2694 mL 0.5387 mL 1.3469 mL
80 mM 0.0404 mL 0.2020 mL 0.4041 mL 1.0102 mL
100 mM 0.0323 mL 0.1616 mL 0.3232 mL 0.8081 mL
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CGS 20625 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGS 20625111205-55-1CGS20625CGS-20625GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorpentylenetetrazolseizuresorally activeanxiolytic activityInhibitorinhibitorinhibit

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