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  3. Chitosan (MW 30000)

Chitosan (MW 30000)  (Synonyms: Deacetylated chitin (MW 30000); Poly(D-glucosamine) (MW 30000))

Cat. No.: HY-B2144B
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Chitosan (MW 30000) (Deacetylated chitin (MW 30000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 30000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities.

For research use only. We do not sell to patients.

Chitosan (MW 30000) Chemical Structure

Chitosan (MW 30000) Chemical Structure

CAS No. : 9012-76-4

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Chitosan (MW 30000):

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Chitosan (MW 30000)

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Chitosan (MW 30000) (Deacetylated chitin (MW 30000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 30000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities[1][2].

In Vitro

Chitosan (2 mg/mL; 48 hours; SKMEL28 and RPMI7951 cells) treatment presents a reduced growth potential[1].
Chitosan (2 mg/mL; 48 hours; RPMI7951 cells) treatment shows potent pro-apoptotic effects against RPMI7951 through the mitochondrial pathway[1].
Chitosan (2 mg/mL; 48 hours; RPMI7951 cells) treatment induces an up regulation of pro-apoptotic molecules such as Bax and a down regulation of anti-apoptotic proteins like Bcl-2 and Bcl-XL[1].
Low-molecular-weight chitosan can penetrate bacterial cell walls, bind with DNA and inhibit DNA transcription and mRNA synthesis, while high-molecular-weight Chitosan can bind to the negatively charged components on the bacterial cell wall. It forms an impermeable layer around the cell, changes cell permeability and blocks transport into the cell. Chitosan also can be used in water treatment, wound-healing materials, pharmaceutical excipient or drug carrier, obesity research and as a scaffold for tissue engineering[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SKMEL28 and RPMI7951 cells
Concentration: 2 mg/mL
Incubation Time: 48 hours
Result: Presented a reduced growth potential.

Apoptosis Analysis[1]

Cell Line: RPMI7951 cells
Concentration: 2 mg/mL
Incubation Time: 48 hours
Result: Had potent pro-apoptotic effects against RPMI7951.

Western Blot Analysis[1]

Cell Line: RPMI7951 cells
Concentration: 2 mg/mL
Incubation Time: 48 hours
Result: Induced an up regulation of pro-apoptotic molecules such as Bax and a down regulation of anti-apoptotic proteins like Bcl-2 and Bcl-XL.
In Vivo

In chemical-induced colonic precancerous lesions in ICR mice, in the 2 weeks preventive experiments, mice fed with a diet containing high molecular weight Chitosan (HMWC) had significant fewer aberrant crypt foci formation than those fed with control diet. As the treatment extended to 6 weeks, both low molecular weight Chitosan (LMWC)- and HMWC-fed mice contained less aberrant crypt foci when compared to control[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

501.48

Formula

C18H35N3O13

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](N)[C@H](O[C@H]3[C@H](O)[C@@H](N)[C@H](O)O[C@@H]3CO)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O.[n].[MW 30000]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

0.1 M HCL : 5 mg/mL (9.97 mM; ultrasonic and warming and heat to 60°C)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9941 mL 9.9705 mL 19.9410 mL
5 mM 0.3988 mL 1.9941 mL 3.9882 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.1 M HCL 1 mM 1.9941 mL 9.9705 mL 19.9410 mL 49.8524 mL
5 mM 0.3988 mL 1.9941 mL 3.9882 mL 9.9705 mL
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Chitosan (MW 30000) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Chitosan (MW 30000)
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HY-B2144B
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