2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. Chk1-IN-6

Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.

For research use only. We do not sell to patients.

Chk1-IN-6 Chemical Structure

Chk1-IN-6 Chemical Structure

CAS No. : 2428423-77-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1109 In-stock
Solution
10 mM * 1 mL in DMSO USD 1109 In-stock
Solid
1 mg USD 460 In-stock
5 mg USD 1380 In-stock
10 mg USD 1950 In-stock
25 mg USD 3500 In-stock
50 mg USD 4900 In-stock
100 mg USD 6860 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Chk1-IN-6 Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.

IC50 & Target

Chk1

 

Cellular Effect
Cell Line Type Value Description References
MV4-11 IC50
0.14 μM
Compound: 6c
Antiproliferation activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Antiproliferation activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 34665631]
Z-138 IC50
3.28 μM
Compound: 6c
Antiproliferation activity against human Z138 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Antiproliferation activity against human Z138 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 34665631]
Molecular Weight

365.36

Formula

C16H18F3N7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC(C=C1)=NC=C1NC2=NC=C(C(F)(F)F)C(NCCC(C)(C)N)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (68.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7370 mL 13.6851 mL 27.3703 mL
5 mM 0.5474 mL 2.7370 mL 5.4741 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7370 mL 13.6851 mL 27.3703 mL 68.4257 mL
5 mM 0.5474 mL 2.7370 mL 5.4741 mL 13.6851 mL
10 mM 0.2737 mL 1.3685 mL 2.7370 mL 6.8426 mL
15 mM 0.1825 mL 0.9123 mL 1.8247 mL 4.5617 mL
20 mM 0.1369 mL 0.6843 mL 1.3685 mL 3.4213 mL
25 mM 0.1095 mL 0.5474 mL 1.0948 mL 2.7370 mL
30 mM 0.0912 mL 0.4562 mL 0.9123 mL 2.2809 mL
40 mM 0.0684 mL 0.3421 mL 0.6843 mL 1.7106 mL
50 mM 0.0547 mL 0.2737 mL 0.5474 mL 1.3685 mL
60 mM 0.0456 mL 0.2281 mL 0.4562 mL 1.1404 mL
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Chk1-IN-6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chk1-IN-62428423-77-0Checkpoint Kinase (Chk)Inhibitorinhibitorinhibit

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