2. Protein Tyrosine Kinase/RTK Apoptosis Stem Cell/Wnt JAK/STAT Signaling
  3. Bcr-Abl Apoptosis STAT
  4. CHMFL-48

CHMFL-48 is an orally active BCR-ABL kinase inhibitor targeting both wild-type (wt) and various imatinib-resistant mutants. The IC50 values for CHMFL-48 against ABL wild-type and ABL T315I mutant are 1 nM and 0.8 nM, respectively. CHMFL-48 exerts its effects by blocking the autophosphorylation of BCR-ABL wild-type and mutant forms, which impacts downstream signaling mediators such as STAT5 and CRKL, leading to cell cycle arrest and induction of apoptosis. CHMFL-48 holds potential for research into chronic myeloid leukemia (CML).

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CHMFL-48 Chemical Structure

CHMFL-48 Chemical Structure

CAS No. : 2479290-65-6

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CHMFL-48 Related Antibodies

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Description

CHMFL-48 is an orally active BCR-ABL kinase inhibitor targeting both wild-type (wt) and various imatinib-resistant mutants. The IC50 values for CHMFL-48 against ABL wild-type and ABL T315I mutant are 1 nM and 0.8 nM, respectively. CHMFL-48 exerts its effects by blocking the autophosphorylation of BCR-ABL wild-type and mutant forms, which impacts downstream signaling mediators such as STAT5 and CRKL, leading to cell cycle arrest and induction of apoptosis. CHMFL-48 holds potential for research into chronic myeloid leukemia (CML)[1].

IC50 & Target

WT BCR-ABL

1 nM (IC50)

Bcr-AblT315I

0.8 nM (IC50)

STAT5

 

Molecular Weight

573.61

Formula

C31H30F3N7O
CAS No.
SMILES

CC1=C(N2C=C(C3=CN=C(NC=C4)C4=C3)C=N2)C=C(NC(C5=CC=C(CN6CCN(C)CC6)C(C(F)(F)F)=C5)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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CHMFL-48 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHMFL-482479290-65-6CHMFL48CHMFL 48Bcr-AblApoptosisSTATChronic myeloid leukemia (CML)Inhibitorinhibitorinhibit

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