Cholesterol-¹³C₃

Name: Cholesterol- 13 C 3
Brand: MedChemExpress
SKU: HY-N0322S4
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0322S4 Purity: 98.8%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Cholesterol-¹³C₃ is the ¹³C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.

For research use only. We do not sell to patients.

Cholesterol-<sup>13</sup>C<sub>3</sub> Chemical Structure

Cholesterol-¹³C₃ Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cholesterol-¹³C₃:

Cholesterol In-stock

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cholesterol-¹³C₃ is the ¹³C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins^[1]^[2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist^[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

389.63

Formula

C₂₄¹³C₃H₄₁O

Unlabeled CAS

57-88-5

Appearance

Solid

Color

White to off-white

SMILES

CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4[13C][13C@@](O)[13C]C[C@]4(C)[C@@]3([H])CC[C@]12C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

Ethanol : 20 mg/mL (51.33 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5665 mL	12.8327 mL	25.6654 mL
5 mM	0.5133 mL	2.5665 mL	5.1331 mL
10 mM	0.2567 mL	1.2833 mL	2.5665 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.8%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (250 KB) MS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Casaburi I, et al. Cholesterol as an Endogenous ERRα Agonist: A New Perspective to Cancer Treatment. Front Endocrinol (Lausanne). 2018 Sep 11;9:525. [Content Brief]

[3]. Dietschy JM, et al. Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res. 2004 Aug;45(8):1375-97. [Content Brief]

[4]. Fukui K, et al. Effect of Cholesterol Reduction on Receptor Signaling in Neurons. J Biol Chem. 2015 Sep 14. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	2.5665 mL	12.8327 mL	25.6654 mL	64.1634 mL
	5 mM	0.5133 mL	2.5665 mL	5.1331 mL	12.8327 mL
	10 mM	0.2567 mL	1.2833 mL	2.5665 mL	6.4163 mL
	15 mM	0.1711 mL	0.8555 mL	1.7110 mL	4.2776 mL
	20 mM	0.1283 mL	0.6416 mL	1.2833 mL	3.2082 mL
	25 mM	0.1027 mL	0.5133 mL	1.0266 mL	2.5665 mL
	30 mM	0.0856 mL	0.4278 mL	0.8555 mL	2.1388 mL
	40 mM	0.0642 mL	0.3208 mL	0.6416 mL	1.6041 mL
	50 mM	0.0513 mL	0.2567 mL	0.5133 mL	1.2833 mL