CI-39

Cat. No.: HY-146364: FAQs
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CI-39 is an antiviral natural product. CI-39 is an NNRTI (non-nucleoside reverse transcriptase inhibit) antiviral agent with an EC₅₀ of 3.40 µM and an CC₅₀ of >30 µM for wild type HIV-1. CI-39 inhibits HIV-1 RT DNA polymerase and ribonuclease H activitiessup.

For research use only. We do not sell to patients.

CI-39 Chemical Structure

CAS No. : 2132412-25-8

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HIV HIV-1 HIV-2

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

HIV-1 (WT)

3.40 μM (EC₅₀)

HIV-1 (WT)

>30 μM (CC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	CC₅₀	> 30 μM Compound: Cl-39	Cytotoxicity against human HEK 293T cells assessed as reduction in cell viability measured after 48 hrs by Celltiter-glo assay Cytotoxicity against human HEK 293T cells assessed as reduction in cell viability measured after 48 hrs by Celltiter-glo assay	[PMID: 32004936]

In Vitro

CI-39 (0-100 µM) inhibits HIV-1 RT DNA polymerase and ribonuclease H activities with EC₅₀s of 7.20, >30 µM, respectively^[1].
CI-39 shows antiviral activities with EC₅₀s of 3.37, 3.00, 2.41, 3.08, 2.14, 3.27, 3.19, 4.07 µM for VSVG/HIV-1_wt, VSVG/HIV-1_RT-K103N, VSVG/HIV-1_wtRT-K103N, VSVG/HIV-1RT-K1_RT-Y181C, VSVG/HIV-1RT-K1_{RT-K103N,Y181C}, VSVG/HIV-1_{RT-K103N,Y181C}, VSVG/HIV-1_{RT-L100I,K103N}, VSVG/HIV-1_RT-Y188L, VSVG/HIV-1_{RT-K103N,G190A}, VSVG/HIV-1_{RT-K103N,V108I}, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

338.36

Formula

C₁₉H₁₈N₂O₄

CAS No.

2132412-25-8

SMILES

O=C(CC1=CN(C2=C1C=CC=C2)OC)NC3=C(C(OC)=O)C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu C, et al. Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root. Eur J Med Chem. 2020 Mar 1;189:112071. [Content Brief]

CI-39 Related Classifications

Infection

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CI-392132412-25-8CI39CI 39HIVHuman immunodeficiency virusNNRTIDNA polymeraseribonuclease Hban lan genInhibitorinhibitorinhibit

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