Cidofovir diphosphate tri(triethylamine)

Name: Cidofovir diphosphate tri(triethylamine)
Brand: MedChemExpress
SKU: HY-131606B
Rating: 4.5 (1 reviews)

Cat. No.: HY-131606B Purity: 98.98%: FAQs
Data Sheet SDS COA Handling Instructions

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Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively.

For research use only. We do not sell to patients.

Cidofovir diphosphate tri(triethylamine) Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2400	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 5200	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Cidofovir diphosphate tri(triethylamine):

Cidofovir diphosphate Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Cidofovir diphosphate tri triethylamine (0-1000 μM) inhibits HCMV, HSV-1, HSV-2, human α, human β and human γ DNA polymerase with K_i values of 6.6, 0.86, 1.4, 51, 520 and 300 μM, respectively^[1].
Cidofovir diphosphate tri triethylamine (0.3-30 μM) inhibits vaccinia virus DNA polymerase with a K_m value of 23 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

742.72

Formula

C₂₆H₆₁N₆O₁₂P₃

Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(O)OP(OP(CO[C@H](CO)CN1C(N=C(C=C1)N)=O)(O)=O)(O)=O.CCN(CC)CC.CCN(CC)CC.CCN(CC)CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (168.30 mM; Need ultrasonic)

DMSO : 125 mg/mL (168.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3464 mL	6.7320 mL	13.4640 mL
5 mM	0.2693 mL	1.3464 mL	2.6928 mL
10 mM	0.1346 mL	0.6732 mL	1.3464 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 12.5 mg/mL (16.83 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.39%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (247 KB) HNMR (288 KB) RP-HPLC (212 KB) MS (186 KB)

Handling Instructions (2659 KB)

References

[1]. Hitchcock MJM, et al. Cidofovir, a New Agent with Potent Anti-Herpesvirus Activity. 1996.

[2]. Magee WC, et al. Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate. Antimicrob Agents Chemother. 2005 Aug;49(8):3153-62. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.3464 mL	6.7320 mL	13.4640 mL	33.6601 mL
	5 mM	0.2693 mL	1.3464 mL	2.6928 mL	6.7320 mL
	10 mM	0.1346 mL	0.6732 mL	1.3464 mL	3.3660 mL
	15 mM	0.0898 mL	0.4488 mL	0.8976 mL	2.2440 mL
	20 mM	0.0673 mL	0.3366 mL	0.6732 mL	1.6830 mL
	25 mM	0.0539 mL	0.2693 mL	0.5386 mL	1.3464 mL
	30 mM	0.0449 mL	0.2244 mL	0.4488 mL	1.1220 mL
	40 mM	0.0337 mL	0.1683 mL	0.3366 mL	0.8415 mL
	50 mM	0.0269 mL	0.1346 mL	0.2693 mL	0.6732 mL
	60 mM	0.0224 mL	0.1122 mL	0.2244 mL	0.5610 mL
	80 mM	0.0168 mL	0.0842 mL	0.1683 mL	0.4208 mL
	100 mM	0.0135 mL	0.0673 mL	0.1346 mL	0.3366 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.