2. Apoptosis
  3. Caspase
  4. Cimiside E

Cimiside E  (Synonyms: 25-Anhydrocimigenol xyloside)

Cat. No.: HY-N10018
Handling Instructions

Molarity Calculator

Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways.

For research use only. We do not sell to patients.

Cimiside E Chemical Structure

Cimiside E Chemical Structure

CAS No. : 154822-57-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Cimiside E Related Antibodies

Top Publications Citing Use of Products

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways[1][2].

IC50 & Target[1]

Caspase 3

 

In Vitro

Cimiside E (30-90 μM; 24 h) arrest cell cycle and induces apoptosis in ASG cells[1].
Cimiside E (30-90 μM; 12-48 h) has a strong cytotoxicity on AGS cells and shows anti-proliferative activity[1].
Cimiside E (15-60 μM; 6-24 h) induces DNA fragment, (30-60; 1-6 h) activates expression of FasL at 3 h and Fas from 1 h in ASG cells[1].
Cimiside E (30-90 μM; 3-24 h) mediates caspase cascade, by increasing Bax/Bcl-2 ratio and decreasing mutant type (mt) p53 and procaspase 3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cimiside E Related Antibodies

Western Blot Analysis[1]

Cell Line: Cimiside E. AGS cells
Concentration: 30 μM, 60 μM, and 90 μM
Incubation Time: 3 h, 6 h, 12 h, and 24 h
Result: Increased the ratio of Bax/Bcl-2 expression from 60 μM.
Decreased mutant type (mt) p53 levle from 12 h at 30 µM.
Suppressed the protein level of procaspase 3 in a dose-dependent manner from 30 μM.

Cell Proliferation Assay[1]

Cell Line: Cimiside E. AGS cells
Concentration: 30 μM, 60 μM, and 90 μM
Incubation Time: 12 h, 24 h, and 48 h
Result: Inhibited ASG cells proliferation with IC50s of 28.7, 14.6 and 8.1 µM, respectively, for 30 μM, 60 μM, and 90 μM treatment.

Cell Cycle Analysis[1]

Cell Line: Cimiside E. AGS cells
Concentration: 30 μM, 60 μM, and 90 μM
Incubation Time: 3 h, 6 h, and 24 h
Result: Induced cell cycle arrest at S phase in a low concentration (30 μM), but arrested cell cycle at G2/M phase in higher concentration (60 μM and 90 μM).
Molecular Weight

602.80

Formula

C35H54O8
CAS No.
SMILES

C[C@]12[C@@]3([H])[C@@]4(CC[C@@]1([C@]5([H])[C@@]6(O[C@]([C@@H](O6)C(C)=C)([H])C[C@H]5C)[C@@H]2O)C)[C@@]7([C@@](C(C)([C@H](CC7)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)C)([H])CC3)C4
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Cimiside E Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cimiside E154822-57-825-Anhydrocimigenol xylosideCaspaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Cimiside E
Cat. No.:
HY-N10018
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.