Cinacalcet-d₃ hydrochloride (Synonyms: AMG 073-d₃ hydrochloride)

Cat. No.: HY-70037AS Purity: 97.63%: FAQs
Data Sheet SDS COA Handling Instructions

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Cinacalcet-d₃ (hydrochloride) is the deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

For research use only. We do not sell to patients.

Cinacalcet-d<sub>3</sub> hydrochloride Chemical Structure

Cinacalcet-d₃ hydrochloride Chemical Structure

Size	Price	Stock	Quantity
500 μg	USD 220	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Other Forms of Cinacalcet-d₃ hydrochloride:

Cinacalcet In-stock
Cinacalcet hydrochloride In-stock
(Rac)-Cinacalcet-d₃ hydrochloride Get quote
(S)-Cinacalcet-d₃ hydrochloride Get quote
Cinacalcet-d₃ Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

396.89

Formula

C₂₂H₂₀D₃ClF₃N

Unlabeled CAS

364782-34-3

Appearance

Solid

Color

White to off-white

SMILES

FC(F)(C1=CC(CCCN[C@@H](C2=C3C=CC=CC3=CC=C2)C([2H])([2H])[2H])=CC=C1)F.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (125.98 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5196 mL	12.5979 mL	25.1959 mL
5 mM	0.5039 mL	2.5196 mL	5.0392 mL
10 mM	0.2520 mL	1.2598 mL	2.5196 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.63%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (247 KB) HNMR (147 KB) RP-HPLC (81 KB) MS (202 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Colloton M, et al. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int. 2005 Feb;67(2):467-76.;D.A. Bushinsky, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69(9):1586-92. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5196 mL	12.5979 mL	25.1959 mL	62.9897 mL
	5 mM	0.5039 mL	2.5196 mL	5.0392 mL	12.5979 mL
	10 mM	0.2520 mL	1.2598 mL	2.5196 mL	6.2990 mL
	15 mM	0.1680 mL	0.8399 mL	1.6797 mL	4.1993 mL
	20 mM	0.1260 mL	0.6299 mL	1.2598 mL	3.1495 mL
	25 mM	0.1008 mL	0.5039 mL	1.0078 mL	2.5196 mL
	30 mM	0.0840 mL	0.4199 mL	0.8399 mL	2.0997 mL
	40 mM	0.0630 mL	0.3149 mL	0.6299 mL	1.5747 mL
	50 mM	0.0504 mL	0.2520 mL	0.5039 mL	1.2598 mL
	60 mM	0.0420 mL	0.2100 mL	0.4199 mL	1.0498 mL
	80 mM	0.0315 mL	0.1575 mL	0.3149 mL	0.7874 mL
	100 mM	0.0252 mL	0.1260 mL	0.2520 mL	0.6299 mL

Cinacalcet-d₃ hydrochloride Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cinacalcet-d₃AMG 073-d₃Isotope-Labeled CompoundsCaSREndogenous MetaboliteCalcium-sensing receptorInhibitorinhibitorinhibit

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Cinacalcet-d3 hydrochloride (Synonyms: AMG 073-d3 hydrochloride)

Other Forms of Cinacalcet-d3 hydrochloride:

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