2. GPCR/G Protein
  3. GLP Receptor
  4. Cinnamtannin A2

Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect.

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Cinnamtannin A2 Chemical Structure

Cinnamtannin A2 Chemical Structure

CAS No. : 86631-38-1

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Based on 1 publication(s) in Google Scholar

Cinnamtannin A2 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect[1][2].

In Vitro

Cinnamtannin A2 (0.125-2.0 μg/mL) inhibits LDL oxidation induced by copper ions or MeO-AMVN[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cinnamtannin A2 Related Antibodies
In Vivo

Cinnamtannin A2 (10 mg/kg; i.p. for 30 days) ameliorates the level of KIM1 and NAGL in 5/6 nephractomized rats by regulating Nrf2- Keap1 pathway[2].
Cinnamtannin A2 (10 μg/kg; p.o.) increases the secretion of insulin and glucagon-like peptide-1 (GLP-1) in plasma of mice[1].
Cinnamtannin A2 (10 μg/kg; p.o.) significantly promotes phosphorylation of both IRB and IRS-1 in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g) were induced chronic renal failure (CRF) by removing the kidneys[2]
Dosage: 10 mg/kg
Administration: I.p. for 30 days
Result: Ameliorated the altered level of creatinine, blood urea nitrogen, Neutrophil gelatinase-associated lipocalin, Kidney Injury Molecule-1 and cytokines in the serum and microalbuminurea.
Reduced the oxidative stress level.
Attenuated the altered expression of proteins involved in Nrf2-Keap1 pathway in the kidney tissue.
Reduced the tubular injury score in the kidney tissue.
Molecular Weight

1155.02

Formula

C60H50O24
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O[C@@H]([C@@H](C(C=C1)=CC(O)=C1O)O2)[C@@H](C(C(O)=C3)=C(O[C@H](C(C=C4)=CC(O)=C4O)[C@@H]5O)C([C@@H]5C(C(O)=C6)=C(O[C@H](C(C=C7)=CC(O)=C7O)[C@@H]8O)C(C8)=C6O)=C3O)C(C2=C([C@H]([C@H]([C@@H](C(C=C9)=CC(O)=C9O)O%10)O)C(C%10=CC(O)=C%11)=C%11O)C(O)=C%12)=C%12O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

Ethanol : ≥ 50 mg/mL (43.29 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8658 mL 4.3289 mL 8.6579 mL
5 mM 0.1732 mL 0.8658 mL 1.7316 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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C2

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Volume (final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.25 mg/mL (1.08 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.25 mg/mL (1.08 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 0.8658 mL 4.3289 mL 8.6579 mL 21.6446 mL
5 mM 0.1732 mL 0.8658 mL 1.7316 mL 4.3289 mL
10 mM 0.0866 mL 0.4329 mL 0.8658 mL 2.1645 mL
15 mM 0.0577 mL 0.2886 mL 0.5772 mL 1.4430 mL
20 mM 0.0433 mL 0.2164 mL 0.4329 mL 1.0822 mL
25 mM 0.0346 mL 0.1732 mL 0.3463 mL 0.8658 mL
30 mM 0.0289 mL 0.1443 mL 0.2886 mL 0.7215 mL
40 mM 0.0216 mL 0.1082 mL 0.2164 mL 0.5411 mL
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Cinnamtannin A2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cinnamtannin A286631-38-1Cinnamtannin A 2Cinnamtannin A-2GLP ReceptortetramericprocyanidinGLP-1insulincorticotrophinantioxidantanti-diabeticnephroprotectiveInhibitorinhibitorinhibit

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