2. GPCR/G Protein
  3. Adenosine Receptor
  4. Cirazoline hydrochloride

Cirazoline hydrochloride  (Synonyms: LD 3098 hydrochloride)

Cat. No.: HY-101300 Purity: 99.65%
COA Handling Instructions

Molarity Calculator

Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full?α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM).

For research use only. We do not sell to patients.

Cirazoline hydrochloride Chemical Structure

Cirazoline hydrochloride Chemical Structure

CAS No. : 40600-13-3

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5 mg USD 170 In-stock
10 mg USD 260 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cirazoline hydrochloride:

Cirazoline hydrochloride Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full?α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM)[1].

In Vitro

Cirazoline hydrochloride (5-10 μM; 24 hours) does not alter GIC survival and counteracted only poorly prazosin‐induced GIC death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cirazoline hydrochloride Related Antibodies

Cell Viability Assay[1]

Cell Line: Glioblastoma‐initiating cells
Concentration: 5 μM; 10 μM
Incubation Time: 24 hours
Result: Did not effect GIC cell survival.
In Vivo

Cirazoline hydrochloride (drinking water; 40 μM; 9 month) exhibits significantly decreased immobility in the TST and enhances neurogenesis in the mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B6/CBA mice[1]
Dosage: 40 μM
Administration: Drinking water; 40 μM; 9 month
Result: Reversed antidepressant-like phenotype of CAM α1A-AR Mice .
Molecular Weight

252.74

Formula

C13H17ClN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.C1(COC2=CC=CC=C2C3CC3)=NCCN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (131.87 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9566 mL 19.7832 mL 39.5664 mL
5 mM 0.7913 mL 3.9566 mL 7.9133 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.65%

COA (253 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.9566 mL 19.7832 mL 39.5664 mL 98.9159 mL
5 mM 0.7913 mL 3.9566 mL 7.9133 mL 19.7832 mL
10 mM 0.3957 mL 1.9783 mL 3.9566 mL 9.8916 mL
15 mM 0.2638 mL 1.3189 mL 2.6378 mL 6.5944 mL
20 mM 0.1978 mL 0.9892 mL 1.9783 mL 4.9458 mL
25 mM 0.1583 mL 0.7913 mL 1.5827 mL 3.9566 mL
30 mM 0.1319 mL 0.6594 mL 1.3189 mL 3.2972 mL
40 mM 0.0989 mL 0.4946 mL 0.9892 mL 2.4729 mL
50 mM 0.0791 mL 0.3957 mL 0.7913 mL 1.9783 mL
60 mM 0.0659 mL 0.3297 mL 0.6594 mL 1.6486 mL
80 mM 0.0495 mL 0.2473 mL 0.4946 mL 1.2364 mL
100 mM 0.0396 mL 0.1978 mL 0.3957 mL 0.9892 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cirazoline hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cirazoline40600-13-3LD 3098LD3098LD-3098Adenosine ReceptorP1 receptorobsessivecompulsivedisorderantidepressantFST glioblastoma‐initiatingcellsGICsCHOInhibitorinhibitorinhibit

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