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  5. Cixutumumab

Cixutumumab  (Synonyms: IMC-A12; NSC742460)

Cat. No.: HY-P99189 Purity: 97.57%
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Cixutumumab (IMC-A12) is a human anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer.

For research use only. We do not sell to patients.

CAS No. : 947687-12-9

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Based on 1 publication(s) in Google Scholar

Cixutumumab Related Antibodies

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Description

Cixutumumab (IMC-A12) is a human anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer[1].

Isotype

Human IgG1 lambda1
Recommend Isotype Controls
Species

Human
IC50 & Target

IGF-1R[1].
In Vitro

Cixutumumab (IMC-A12) (0.01-100 nM; 96 h) exhibits at least 50% growth inhibition in CHLA-9, TC-71and Rh41 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cixutumumab Related Antibodies

Cell Viability Assay[1]

Cell Line: CHLA-9, TC-71, Rh41 cells
Concentration: 0.01-100 nM
Incubation Time: 96 h
Result: Inhibited CHLA-9, TC-71and Rh41 cells growth with IC50 values of 49.31, 0.66 and 0.04 nM, respectively.
In Vivo

Cixutumumab (IMC-A12) (1 mg/rat; i.p.; twice weekly for 6 weeks) shows broad-spectrum antitumor activity, inhibits tumor growth of the PPTP’s in vivo solid tumor panels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CB17SC-M scid-/- female mice (solid tumor xenografts model)[1].
Dosage: 1 mg/rat
Administration: Intraperitoneal injection; twice weekly for 6 weeks.
Result: Demonstrated broad antitumor activity against the PPTP’s in vivo solid tumor panels, with the activity primarily being tumor growth inhibition rather than tumor regression.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Cixutumumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
Purity & Documentation
References
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Cixutumumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cixutumumab947687-12-9IMC-A12 NSC742460NSC742460NSC 742460NSC-742460OthersCHLA-9TC-71Rh41cancerprostate cancermalignancieslung cancerInhibitorinhibitorinhibit

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