2. PROTAC
  3. PROTAC Linkers
  4. Cl-PEG4-acid

Cl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Cl-PEG4-acid Chemical Structure

Cl-PEG4-acid Chemical Structure

CAS No. : 158553-98-1

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Based on 1 publication(s) in Google Scholar

Cl-PEG4-acid Related Antibodies

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Description

Cl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cl-PEG4-acid Related Antibodies
Molecular Weight

270.71

Formula

C10H19ClO6
CAS No.
Appearance

Liquid (Density: 1.202 g/cm3)

Color

Colorless to light yellow

SMILES

OC(COCCOCCOCCOCCCl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 200 mg/mL (738.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6940 mL 18.4699 mL 36.9399 mL
5 mM 0.7388 mL 3.6940 mL 7.3880 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (240 KB) HNMR (239 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6940 mL 18.4699 mL 36.9399 mL 92.3497 mL
5 mM 0.7388 mL 3.6940 mL 7.3880 mL 18.4699 mL
10 mM 0.3694 mL 1.8470 mL 3.6940 mL 9.2350 mL
15 mM 0.2463 mL 1.2313 mL 2.4627 mL 6.1566 mL
20 mM 0.1847 mL 0.9235 mL 1.8470 mL 4.6175 mL
25 mM 0.1478 mL 0.7388 mL 1.4776 mL 3.6940 mL
30 mM 0.1231 mL 0.6157 mL 1.2313 mL 3.0783 mL
40 mM 0.0923 mL 0.4617 mL 0.9235 mL 2.3087 mL
50 mM 0.0739 mL 0.3694 mL 0.7388 mL 1.8470 mL
60 mM 0.0616 mL 0.3078 mL 0.6157 mL 1.5392 mL
80 mM 0.0462 mL 0.2309 mL 0.4617 mL 1.1544 mL
100 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9235 mL
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Cl-PEG4-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cl-PEG4-acid158553-98-1PROTAC LinkersInhibitorinhibitorinhibit

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