2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. CL2A TFA

CL2A TFA is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A TFA is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker.

For research use only. We do not sell to patients.

CL2A TFA Chemical Structure

CL2A TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 580 In-stock
10 mg USD 950 In-stock
50 mg USD 1600 In-stock
100 mg USD 2250 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of CL2A TFA:

CL2A TFA Related Antibodies

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Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

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Description

CL2A TFA is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A TFA is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker[1].

Molecular Weight

1176.24

Formula

C52H80F3N9O18
Appearance

Solid

SMILES

O=C(O)C(F)(F)F.O=C(NC1=CC=C(CO)C=C1)[C@H](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN2N=NC(CNC(C3CCC(CN4C(C=CC4=O)=O)CC3)=O)=C2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 222.5 mg/mL (189.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8502 mL 4.2508 mL 8.5017 mL
5 mM 0.1700 mL 0.8502 mL 1.7003 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8502 mL 4.2508 mL 8.5017 mL 21.2542 mL
5 mM 0.1700 mL 0.8502 mL 1.7003 mL 4.2508 mL
10 mM 0.0850 mL 0.4251 mL 0.8502 mL 2.1254 mL
15 mM 0.0567 mL 0.2834 mL 0.5668 mL 1.4169 mL
20 mM 0.0425 mL 0.2125 mL 0.4251 mL 1.0627 mL
25 mM 0.0340 mL 0.1700 mL 0.3401 mL 0.8502 mL
30 mM 0.0283 mL 0.1417 mL 0.2834 mL 0.7085 mL
40 mM 0.0213 mL 0.1063 mL 0.2125 mL 0.5314 mL
50 mM 0.0170 mL 0.0850 mL 0.1700 mL 0.4251 mL
60 mM 0.0142 mL 0.0708 mL 0.1417 mL 0.3542 mL
80 mM 0.0106 mL 0.0531 mL 0.1063 mL 0.2657 mL
100 mM 0.0085 mL 0.0425 mL 0.0850 mL 0.2125 mL
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CL2A TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL2AADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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