CL2A

Cat. No.: HY-128945: FAQs
Data Sheet SDS Handling Instructions

Molarity Calculator

CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker.

For research use only. We do not sell to patients.

CL2A Chemical Structure

CAS No. : 2616704-22-2

Size	Price	Stock
5 mg	USD 580	Ask For Quote & Lead Time
10 mg	USD 950	Ask For Quote & Lead Time
50 mg	USD 1600	Ask For Quote & Lead Time
100 mg	USD 2250	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of CL2A:

CL2A TFA Get quote

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•Related Small Molecules:

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View All Isoforms

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Cleavable Linker

Molecular Weight

1062.21

Formula

C₅₀H₇₉N₉O₁₆

CAS No.

2616704-22-2

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(NC1=CC=C(CO)C=C1)[C@H](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN2N=NC(CNC(C3CCC(CN4C(C=CC4=O)=O)CC3)=O)=C2)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (188.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9414 mL	4.7072 mL	9.4143 mL
5 mM	0.1883 mL	0.9414 mL	1.8829 mL
10 mM	0.0941 mL	0.4707 mL	0.9414 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (268 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Samantha Congreve, et al. Antibody drug conjugates (ADC). Teknisk- naturvetenskaplig fakultet

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9414 mL	4.7072 mL	9.4143 mL	23.5358 mL
	5 mM	0.1883 mL	0.9414 mL	1.8829 mL	4.7072 mL
	10 mM	0.0941 mL	0.4707 mL	0.9414 mL	2.3536 mL
	15 mM	0.0628 mL	0.3138 mL	0.6276 mL	1.5691 mL
	20 mM	0.0471 mL	0.2354 mL	0.4707 mL	1.1768 mL
	25 mM	0.0377 mL	0.1883 mL	0.3766 mL	0.9414 mL
	30 mM	0.0314 mL	0.1569 mL	0.3138 mL	0.7845 mL
	40 mM	0.0235 mL	0.1177 mL	0.2354 mL	0.5884 mL
	50 mM	0.0188 mL	0.0941 mL	0.1883 mL	0.4707 mL
	60 mM	0.0157 mL	0.0785 mL	0.1569 mL	0.3923 mL
	80 mM	0.0118 mL	0.0588 mL	0.1177 mL	0.2942 mL
	100 mM	0.0094 mL	0.0471 mL	0.0941 mL	0.2354 mL

CL2A Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL2A2616704-22-2ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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