2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. CL2A

CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker.

For research use only. We do not sell to patients.

CL2A Chemical Structure

CL2A Chemical Structure

CAS No. : 2616704-22-2

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10 mg USD 950 Ask For Quote & Lead Time
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CL2A Related Antibodies

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Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

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Description

CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker[1].

IC50 & Target[1]

Cleavable Linker

 

Molecular Weight

1062.21

Formula

C50H79N9O16
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(NC1=CC=C(CO)C=C1)[C@H](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN2N=NC(CNC(C3CCC(CN4C(C=CC4=O)=O)CC3)=O)=C2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (188.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9414 mL 4.7072 mL 9.4143 mL
5 mM 0.1883 mL 0.9414 mL 1.8829 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9414 mL 4.7072 mL 9.4143 mL 23.5358 mL
5 mM 0.1883 mL 0.9414 mL 1.8829 mL 4.7072 mL
10 mM 0.0941 mL 0.4707 mL 0.9414 mL 2.3536 mL
15 mM 0.0628 mL 0.3138 mL 0.6276 mL 1.5691 mL
20 mM 0.0471 mL 0.2354 mL 0.4707 mL 1.1768 mL
25 mM 0.0377 mL 0.1883 mL 0.3766 mL 0.9414 mL
30 mM 0.0314 mL 0.1569 mL 0.3138 mL 0.7845 mL
40 mM 0.0235 mL 0.1177 mL 0.2354 mL 0.5884 mL
50 mM 0.0188 mL 0.0941 mL 0.1883 mL 0.4707 mL
60 mM 0.0157 mL 0.0785 mL 0.1569 mL 0.3923 mL
80 mM 0.0118 mL 0.0588 mL 0.1177 mL 0.2942 mL
100 mM 0.0094 mL 0.0471 mL 0.0941 mL 0.2354 mL
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CL2A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL2A2616704-22-2ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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