1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. Clopidogrel carboxylic acid hydrochloride

Clopidogrel carboxylic acid hydrochloride  (Synonyms: CLPM hydrochloride; SR 26334 hydrochloride)

Cat. No.: HY-141749B Purity: 99.50%
Handling Instructions Technical Support

Clopidogrel carboxylic acid (CLPM) hydrochloride is an inactive metabolite of the widely used antiplatelet medication clopidogrel, which serves as a reference standard for quantitative analysis of clopidogrel metabolism. Clopidogrel carboxylic acid hydrochloride has been shown to represent approximately 85% of circulating clopidogrel, hydrolyzed from the active form by esterases. Clopidogrel carboxylic acid hydrochloride plays a crucial role in assessing the pharmacokinetics and bioavailability of clopidogrel in various clinical and research settings.

For research use only. We do not sell to patients.

Clopidogrel carboxylic acid hydrochloride Chemical Structure

Clopidogrel carboxylic acid hydrochloride Chemical Structure

CAS No. : 144750-42-5

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Description

Clopidogrel carboxylic acid (CLPM) hydrochloride is an inactive metabolite of the widely used antiplatelet medication clopidogrel, which serves as a reference standard for quantitative analysis of clopidogrel metabolism. Clopidogrel carboxylic acid hydrochloride has been shown to represent approximately 85% of circulating clopidogrel, hydrolyzed from the active form by esterases. Clopidogrel carboxylic acid hydrochloride plays a crucial role in assessing the pharmacokinetics and bioavailability of clopidogrel in various clinical and research settings.

Molecular Weight

344.26

Formula

C15H15Cl2NO2S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@H](C1=C(C=CC=C1)Cl)N2CC3=C(SC=C3)CC2)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (363.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9048 mL 14.5239 mL 29.0478 mL
5 mM 0.5810 mL 2.9048 mL 5.8096 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9048 mL 14.5239 mL 29.0478 mL 72.6195 mL
5 mM 0.5810 mL 2.9048 mL 5.8096 mL 14.5239 mL
10 mM 0.2905 mL 1.4524 mL 2.9048 mL 7.2620 mL
15 mM 0.1937 mL 0.9683 mL 1.9365 mL 4.8413 mL
20 mM 0.1452 mL 0.7262 mL 1.4524 mL 3.6310 mL
25 mM 0.1162 mL 0.5810 mL 1.1619 mL 2.9048 mL
30 mM 0.0968 mL 0.4841 mL 0.9683 mL 2.4207 mL
40 mM 0.0726 mL 0.3631 mL 0.7262 mL 1.8155 mL
50 mM 0.0581 mL 0.2905 mL 0.5810 mL 1.4524 mL
60 mM 0.0484 mL 0.2421 mL 0.4841 mL 1.2103 mL
80 mM 0.0363 mL 0.1815 mL 0.3631 mL 0.9077 mL
100 mM 0.0290 mL 0.1452 mL 0.2905 mL 0.7262 mL
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Clopidogrel carboxylic acid hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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