2. Immunology/Inflammation
  3. SOD
  4. CMB-087229

CMB-087229 is a mutant superoxide dismutase 1 (SOD1) protein aggregation inhibitor with IC50 of 67 nM, which can be used in the research of amyotrophic lateral sclerosis.

For research use only. We do not sell to patients.

CMB-087229 Chemical Structure

CMB-087229 Chemical Structure

CAS No. : 1227692-67-2

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Based on 1 publication(s) in Google Scholar

CMB-087229 Related Antibodies

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Description

CMB-087229 is a mutant superoxide dismutase 1 (SOD1) protein aggregation inhibitor with IC50 of 67 nM, which can be used in the research of amyotrophic lateral sclerosis[1].

Cellular Effect
Cell Line Type Value Description References
PC-12 EC50
0.067 μM
Compound: 5a
Neuroprotective activity in rat PC12 cells expressing SOD1 G93A mutant assessed as increase in cell viability after 48 hrs by CalceinAM-based fluorescence assay
Neuroprotective activity in rat PC12 cells expressing SOD1 G93A mutant assessed as increase in cell viability after 48 hrs by CalceinAM-based fluorescence assay
[PMID: 23021992]
PC-12 EC50
0.067 μM
Compound: 13
Inhibition of SOD1 G93A mutant aggregation-induced cytotoxicity in rat PC12 cells incubated for 24 hrs and measured 72 hrs post compound dose by cytotoxicity protection assay
Inhibition of SOD1 G93A mutant aggregation-induced cytotoxicity in rat PC12 cells incubated for 24 hrs and measured 72 hrs post compound dose by cytotoxicity protection assay
[PMID: 22191331]
Molecular Weight

259.09

Formula

C10H8Cl2N2O2
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C1C=C(COC2=CC(Cl)=CC(Cl)=C2)NN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (482.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8597 mL 19.2983 mL 38.5966 mL
5 mM 0.7719 mL 3.8597 mL 7.7193 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8597 mL 19.2983 mL 38.5966 mL 96.4916 mL
5 mM 0.7719 mL 3.8597 mL 7.7193 mL 19.2983 mL
10 mM 0.3860 mL 1.9298 mL 3.8597 mL 9.6492 mL
15 mM 0.2573 mL 1.2866 mL 2.5731 mL 6.4328 mL
20 mM 0.1930 mL 0.9649 mL 1.9298 mL 4.8246 mL
25 mM 0.1544 mL 0.7719 mL 1.5439 mL 3.8597 mL
30 mM 0.1287 mL 0.6433 mL 1.2866 mL 3.2164 mL
40 mM 0.0965 mL 0.4825 mL 0.9649 mL 2.4123 mL
50 mM 0.0772 mL 0.3860 mL 0.7719 mL 1.9298 mL
60 mM 0.0643 mL 0.3216 mL 0.6433 mL 1.6082 mL
80 mM 0.0482 mL 0.2412 mL 0.4825 mL 1.2061 mL
100 mM 0.0386 mL 0.1930 mL 0.3860 mL 0.9649 mL
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CMB-087229 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CMB-0872291227692-67-2CMB087229CMB 087229SODSuperoxide DismutaseInhibitorinhibitorinhibit

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HY-148901
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