COG 133

Cat. No.: HY-P1050: FAQs
Data Sheet Handling Instructions

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COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC₅₀ of 445 nM.

For research use only. We do not sell to patients.

COG 133 Chemical Structure

CAS No. : 514200-66-9

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Other Forms of COG 133:

COG 133 TFA Get quote

2 Publications Citing Use of MCE COG 133

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: 445 nM (nAChR)^[2]

In Vivo

COG 133 (1 mg/kg; intratracheal administration; every other day; for 4 weeks) treatment impairs the resolution of pulmonary fibrosis in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 mice (6-week-old) instilled with Bleomycin^[3]
Dosage:	1 mg/kg
Administration:	Intratracheal administration; every other day; for 4 weeks
Result:	Did blunt the resolution of lung fibrosis.

Molecular Weight

2169.71

Formula

C₉₇H₁₈₁N₃₇O₁₉

CAS No.

514200-66-9

Sequence

Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2

Sequence Shortening

Ac-LRVRLASHLRKLRKRLL-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Orleâncio Gomes R Azevedo, et al. Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. BMC Gastroenterol. 2012 Jul 13;12:35. [Content Brief]

[2]. Elaine A Gay, et al. Apolipoprotein E-derived peptides block alpha7 neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes. J Pharmacol Exp Ther. 2006 Feb;316(2):835-42. [Content Brief]

[3]. Huachun Cui, et al. Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution. JCI Insight. 2020 Mar 12;5(5):e134539. [Content Brief]

COG 133 Related Classifications

Neurological Disease Inflammation/Immunology

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COG 133514200-66-9COG133COG-133nAChRNicotinic acetylcholine receptorsAPOEmimicsLDLanti-inflammatoryneuroprotectiveInhibitorinhibitorinhibit

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