2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. COG 133

COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

COG 133 Chemical Structure

COG 133 Chemical Structure

CAS No. : 514200-66-9

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Based on 2 publication(s) in Google Scholar

Other Forms of COG 133:

COG 133 Related Antibodies

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Description

COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2].

IC50 & Target

IC50: 445 nM (nAChR)[2]
In Vivo

COG 133 (1 mg/kg; intratracheal administration; every other day; for 4 weeks) treatment impairs the resolution of pulmonary fibrosis in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (6-week-old) instilled with Bleomycin[3]
Dosage: 1 mg/kg
Administration: Intratracheal administration; every other day; for 4 weeks
Result: Did blunt the resolution of lung fibrosis.
Molecular Weight

2169.71

Formula

C97H181N37O19
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2
Sequence Shortening

Ac-LRVRLASHLRKLRKRLL-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (46.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4609 mL 2.3045 mL 4.6089 mL
5 mM 0.0922 mL 0.4609 mL 0.9218 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4609 mL 2.3045 mL 4.6089 mL 11.5223 mL
5 mM 0.0922 mL 0.4609 mL 0.9218 mL 2.3045 mL
10 mM 0.0461 mL 0.2304 mL 0.4609 mL 1.1522 mL
15 mM 0.0307 mL 0.1536 mL 0.3073 mL 0.7682 mL
20 mM 0.0230 mL 0.1152 mL 0.2304 mL 0.5761 mL
25 mM 0.0184 mL 0.0922 mL 0.1844 mL 0.4609 mL
30 mM 0.0154 mL 0.0768 mL 0.1536 mL 0.3841 mL
40 mM 0.0115 mL 0.0576 mL 0.1152 mL 0.2881 mL
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COG 133 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COG 133514200-66-9COG133COG-133nAChRNicotinic acetylcholine receptorsAPOEmimicsLDLanti-inflammatoryneuroprotectiveInhibitorinhibitorinhibit

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