2. Inhibitory Antibodies
  3. Concizumab

Concizumab  (Synonyms: NN 7415; mAb 2021; Anti-TFPI Recombinant Antibody)

Cat. No.: HY-P99283 Purity: 95.00%
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Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that binds to the Kunitz-type protease inhibitor (KPI) 2 structural domain of TFPI, thereby blocking the interaction of this structural domain with the FXa active site. Concizumab can be used in the study of haemophilia.

For research use only. We do not sell to patients.

CAS No. : 1312299-39-0

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Concizumab Related Antibodies

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Description

Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that binds to the Kunitz-type protease inhibitor (KPI) 2 structural domain of TFPI, thereby blocking the interaction of this structural domain with the FXa active site. Concizumab can be used in the study of haemophilia[1][2].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Humanized
IC50 & Target

TFPI[1][2].
In Vitro

Concizumab increases thrombin peak in a concentration- dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Concizumab Related Antibodies
In Vivo

Concizumab (i.v./s.c.) blocks the TFPI interaction with the active site of FXa in cynomolgus monkeys[2].
1.19 Pharmacokinetic parameters after intravenous or subcutaneous administration of Concizumab to cynomolgus monkeys[2].

Parameter Unit Estimate %RSE
CLL mL/h/kg 0.14 6.1
V1 mL/kg 33 34
V2 mL/kg 33 -
Q mL/h/kg 0.12 16
F % 93 7.7
Vmax µg/h/kg 11 17
Km µg/mL 0.54 52
t1/2(abs) h 72 32

CLL: the linear part of the clearance.
V1: the volume of the central compartment.
V2: the volume of the peripheral compartment.
Vmax: the maximum amount of anti-TFPI cleared per time unit via binding to TFPI.
Km: the concentration at which the target mediated elimination rate is 50% of the maximum value (Vmax).
T1/2(abs): the absorption half-life, describing the rate of absorption after sc administration.
%RSE: residual standard error.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys (target mediated drug disposition (TMDD) model)[2].
Dosage: 20mg/kg or 200 mg/kg
Administration: Intravenous injection/subcutaneous injection
Result: Showed a high bioavailability (93%) and the absorption half-life is estimated to be 72 h.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Concizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Purity & Documentation
References
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Concizumab Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Concizumab1312299-39-0NN 7415 mAb 2021 Anti-TFPI Recombinant AntibodyNN7415NN-7415mAb2021mAb 2021mAb-2021Othershemophilia(KPI) 2FXathrombinInhibitorinhibitorinhibit

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