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  3. Bacterial
  4. Coproporphyrin III dihydrochloride

Coproporphyrin III dihydrochloride  (Synonyms: Zincphyrin dihydrochloride)

Cat. No.: HY-W412175 Purity: 98.71%
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Coproporphyrin III dihydrochloride is a bioactive molecule excreted by nostril- and skin-associated Propionibacterium species that induces aggregation of Staphylococcus aureus (conditions: during early stationary phase growth, low pH: 4-6). Coproporphyrin III dihydrochloride also induces plasma-independent biofilm formation on abiotic surfaces by Staphylococcus aureus. Coproporphyrin III dihydrochloride may be an important mediator of S. aureus accumulation and/or biofilm formation in the nostrils or other sites where Propionibacterium and S. aureus inhabit.

For research use only. We do not sell to patients.

Coproporphyrin III dihydrochloride Chemical Structure

Coproporphyrin III dihydrochloride Chemical Structure

CAS No. : 68938-73-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Coproporphyrin III dihydrochloride:

Coproporphyrin III dihydrochloride Related Antibodies

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Description

Coproporphyrin III dihydrochloride is a bioactive molecule excreted by nostril- and skin-associated Propionibacterium species that induces aggregation of Staphylococcus aureus (conditions: during early stationary phase growth, low pH: 4-6). Coproporphyrin III dihydrochloride also induces plasma-independent biofilm formation on abiotic surfaces by Staphylococcus aureus. Coproporphyrin III dihydrochloride may be an important mediator of S. aureus accumulation and/or biofilm formation in the nostrils or other sites where Propionibacterium and S. aureus inhabit[1].

Molecular Weight

727.63

Formula

C36H40Cl2N4O8
CAS No.
Appearance

Solid

Color

Purple to purplish red

SMILES

O=C(O)CCC1=C2/C=C3C(CCC(O)=O)=C(C)C(/C=C(N/4)/C(C)=C(CCC(O)=O)C4=C\C5=N/C(C(CCC(O)=O)=C5C)=C\C(N2)=C1C)=N/3.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (137.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3743 mL 6.8716 mL 13.7432 mL
5 mM 0.2749 mL 1.3743 mL 2.7486 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3743 mL 6.8716 mL 13.7432 mL 34.3581 mL
5 mM 0.2749 mL 1.3743 mL 2.7486 mL 6.8716 mL
10 mM 0.1374 mL 0.6872 mL 1.3743 mL 3.4358 mL
15 mM 0.0916 mL 0.4581 mL 0.9162 mL 2.2905 mL
20 mM 0.0687 mL 0.3436 mL 0.6872 mL 1.7179 mL
25 mM 0.0550 mL 0.2749 mL 0.5497 mL 1.3743 mL
30 mM 0.0458 mL 0.2291 mL 0.4581 mL 1.1453 mL
40 mM 0.0344 mL 0.1718 mL 0.3436 mL 0.8590 mL
50 mM 0.0275 mL 0.1374 mL 0.2749 mL 0.6872 mL
60 mM 0.0229 mL 0.1145 mL 0.2291 mL 0.5726 mL
80 mM 0.0172 mL 0.0859 mL 0.1718 mL 0.4295 mL
100 mM 0.0137 mL 0.0687 mL 0.1374 mL 0.3436 mL
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Coproporphyrin III dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Coproporphyrin III68938-73-8ZincphyrinBacterialPropionibacterium spp.Staphylococcus aureusplasma-independent biofilmsInhibitorinhibitorinhibit

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