2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. Cortistatin-14

Cortistatin-14 is a neuropeptide that shares structural similarities with somatostatin, working by binding to somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) has anticonvulsant, neuroprotective effects, and significant anti-inflammatory properties.

For research use only. We do not sell to patients.

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Cortistatin-14 Chemical Structure

Cortistatin-14 Chemical Structure

CAS No. : 186901-48-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Cortistatin-14:

Cortistatin-14 Related Antibodies

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SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cortistatin-14 is a neuropeptide that shares structural similarities with somatostatin, working by binding to somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) has anticonvulsant, neuroprotective effects, and significant anti-inflammatory properties[1][2][3].

IC50 & Target

SSTR1

 

SSTR2

 

SSTR3

 

SSTR4

 

SSTR5

 

In Vitro

Cortistatin-14 (100-10000 nM, 8-24 min) reduces the release of calcitonin gene-related peptide from peripheral sensory nerve endings in the isolated trachea of rats induced by capsaicin (HY-10448) [1].
CST-14 (0.1-10 μg/mL, 8 h) significantly decreases the secretion of the cytokine IL-1β in mouse peritoneal macrophages [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cortistatin-14 Related Antibodies
In Vivo

Cortistatin-14 (10-250 μg/kg; injected in the footpad or intraperitoneal injection; six times a day) reduces acute neurogenic plasma protein leakage in the hind paw skin of rats caused by mustard oil, as well as carrageenan-induced paw edema in mice, mechanical hyperalgesia, the production of IL-1β and tumor necrosis factor-α, and mild heat injury-induced thermal hyperalgesia[1].
Cortistatin-14 (10 μg; intravenous injection; single dose) plays a regulatory role in the pituitary secretion of male rats[2].
Cortistatin-14 (1-10 nM, intracerebroventricular injection; single dose) has anticonvulsant and neuroprotective effects in rats by binding to somatostatin receptors, which leads to a reduction in the release of excitatory neurotransmitters[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hydrochloride-induced rat[3]
Dosage: 1 and 10 nM; single dose
Administration: Intracerebroventricular injection (ICV)
Result: Relieved epilepsy, inhibited neuronal loss, prevented the reduction of immune-active somatostatin and its receptors in the hippocampus, and reduced the release of 3H-D-aspartate under stimulation.
Animal Model: Endotoxin-stimulated mice[1]
Dosage: 10 μg/kg (i.p.); 100 μg/kg (i.p.); 250 μg/kg (i.pl.); six times a day
Administration: Intraperitoneal injection (i.p.); i.pl.
Result: Reduced the concentrations of TNF-α and IL-1β, reduced mustard oil-induced plasma protein extravasation in the dorsal skin, with an inhibition rate of nearly 80%, inhibited plantar thermal hyperalgesia in rats caused by mild thermal injury (51°C, 20 seconds).
Animal Model: Wistar-Kyoto rat[2]
Dosage: 10 μg; single dose
Administration: Intravenous injection (i.v.)
Result: Reduced growth hormone concentrations without affecting LH and FSH concentrations.
Molecular Weight

1720.03

Formula

C81H114N20O18S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Pro}{Cys}{Lys}{Asn}{Phe}{Phe}{Trp}{Lys}{Thr}{Phe}{Ser}{Ser}{Cys}{Lys}-NH2 (Disulfide bridge: Cys2-Cys13)
Sequence Shortening

PCKNFFWKTFSSCK-NH2 (Disulfide bridge: Cys2-Cys13)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (58.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5814 mL 2.9069 mL 5.8139 mL
5 mM 0.1163 mL 0.5814 mL 1.1628 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (58.14 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.21%

SDS (252 KB)

COA (265 KB) LCMS (87 KB) Elemental Analysis Report (124 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5814 mL 2.9069 mL 5.8139 mL 14.5346 mL
5 mM 0.1163 mL 0.5814 mL 1.1628 mL 2.9069 mL
10 mM 0.0581 mL 0.2907 mL 0.5814 mL 1.4535 mL
15 mM 0.0388 mL 0.1938 mL 0.3876 mL 0.9690 mL
20 mM 0.0291 mL 0.1453 mL 0.2907 mL 0.7267 mL
25 mM 0.0233 mL 0.1163 mL 0.2326 mL 0.5814 mL
30 mM 0.0194 mL 0.0969 mL 0.1938 mL 0.4845 mL
40 mM 0.0145 mL 0.0727 mL 0.1453 mL 0.3634 mL
50 mM 0.0116 mL 0.0581 mL 0.1163 mL 0.2907 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cortistatin-14 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cortistatin-14186901-48-4Cortistatin14Cortistatin 14Somatostatin ReceptorSSTRsSSTRAnticonvulsantneuroprotectiveanti-inflammatoryInhibitorinhibitorinhibit

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