2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. Cortistatin-29

Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.

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Cortistatin-29 Chemical Structure

Cortistatin-29 Chemical Structure

CAS No. : 1815618-17-7

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Cortistatin-29 Related Antibodies

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SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

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Description

Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects[1][2][3][4].

IC50 & Target[3]

SSTR1

2.8 nM (IC50)

SSTR2

7.1 nM (IC50)

SSTR3

0.2 nM (IC50)

SSTR4

3.0 nM (IC50)

SSTR5

13.7 nM (IC50)

In Vivo

Cortistatin 29 (1-2 µg) alleviates chronic neuropathic pain in mouse[1].
Cortistatin 29 (1 nmol/mouse; i.p.; three times weekly) shows anti-fibrotic effects in mouse[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20-24 g body weight, 8-12 weeks-old mice[1]
Dosage: 1 µg in 20 µL for s.c.; 2 µg in 200 µL for i.p.; 20 ng in 10 µL for i.t.
Administration: Every other day for 12 days
Result: Ameliorated hyperalgesia and allodynia, regulated the nerve damageinduced hypersensitization of primary nociceptors, inhibited neuroinflammatory responses, and enhanced the production of neurotrophic factors both at the peripheral and central levels.
Molecular Weight

3540.04

Formula

C161H240N46O41S2
CAS No.
Sequence

{Glp}-Glu-Arg-Pro-Pro-Leu-Gln-Gln-Pro-Pro-His-Arg-Asp-Lys-Lys-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys (disulfide bridge: Cys17-Cys28)
Sequence Shortening

{Glp}-ERPPLQQPPHRDKKPCKNFFWKTFSSCK (disulfide bridge: Cys17-Cys28)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cortistatin-29 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cortistatin-291815618-17-7Cortistatin29Cortistatin 29Somatostatin ReceptorSSTRsSSTRanti-fibroticneuropathic painneuropeptidecontractile fibersInhibitorinhibitorinhibit

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