COX-1-IN-1

Cat. No.: HY-162167: FAQs
Data Sheet Handling Instructions

Molarity Calculator

COX-1-IN-1 (compound 15a) is a selective inhibitor for cyclooxygenase (COX), with IC₅₀s of 0.23 μM (COX-1) and >50 μM (COX-2), selective index (COX-2 IC₅₀/COX-1 IC₅₀) is 217. COX-1-IN-1 inhibits platelet aggregation.

For research use only. We do not sell to patients.

COX-1-IN-1 Chemical Structure

CAS No. : 1369503-03-6

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All COX Isoform Specific Products:

View All Isoforms

COX COX-1 COX-2 COX-3

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

COX-1

0.23 μM (IC₅₀)

COX-2

50 μM (IC₅₀)

In Vitro

COX-1-IN-1 inhibits arachidonic acid (AA) induced platelet aggregation with IC₅₀ of 1 μM. COX-1-IN-1 (100 μM, 3 h) reveals low cytotoxicity for cells and platelets^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	Vero
Concentration:	100 μM
Incubation Time:	3 h
Result:	Revealed platelet and cell viabilities above 90%.

Molecular Weight

323.39

Formula

C₂₀H₂₁NO₃

CAS No.

1369503-03-6

SMILES

CCOC1=CC=C(C2=NOC(C)=C2C3=CC=C(OCC)C=C3)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Solidoro R,et al., A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior. Eur J Med Chem. 2024 Feb 15;266:116135. [Content Brief]

COX-1-IN-1 Related Classifications

Neurological Disease Cardiovascular Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-1-IN-11369503-03-6COXCyclooxygenasecardiovascularneurologicalneurodegenerative diseaseplateletVeroInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks