2. Immunology/Inflammation
  3. COX
  4. COX-1-IN-1

COX-1-IN-1 (compound 15a) is a selective inhibitor for cyclooxygenase (COX), with IC50s of 0.23 μM (COX-1) and >50 μM (COX-2), selective index (COX-2 IC50/COX-1 IC50) is 217. COX-1-IN-1 inhibits platelet aggregation.

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COX-1-IN-1 Chemical Structure

COX-1-IN-1 Chemical Structure

CAS No. : 1369503-03-6

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COX-1-IN-1 Related Antibodies

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COX COX-1 COX-2 COX-3

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Description

COX-1-IN-1 (compound 15a) is a selective inhibitor for cyclooxygenase (COX), with IC50s of 0.23 μM (COX-1) and >50 μM (COX-2), selective index (COX-2 IC50/COX-1 IC50) is 217. COX-1-IN-1 inhibits platelet aggregation[1].

IC50 & Target

COX-1

0.23 μM (IC50)

COX-2

50 μM (IC50)

In Vitro

COX-1-IN-1 inhibits arachidonic acid (AA) induced platelet aggregation with IC50 of 1 μM. COX-1-IN-1 (100 μM, 3 h) reveals low cytotoxicity for cells and platelets[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

COX-1-IN-1 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Vero
Concentration: 100 μM
Incubation Time: 3 h
Result: Revealed platelet and cell viabilities above 90%.
Molecular Weight

323.39

Formula

C20H21NO3
CAS No.
SMILES

CCOC1=CC=C(C2=NOC(C)=C2C3=CC=C(OCC)C=C3)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-1-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-1-IN-11369503-03-6COXCyclooxygenasecardiovascularneurologicalneurodegenerative diseaseplateletVeroInhibitorinhibitorinhibit

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