2. Immunology/Inflammation Metabolic Enzyme/Protease NF-κB
  3. COX Lipoxygenase NF-κB
  4. COX-2/15-LOX-IN-5

COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities.

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COX-2/15-LOX-IN-5 Chemical Structure

COX-2/15-LOX-IN-5 Chemical Structure

CAS No. : 443790-30-5

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COX-2/15-LOX-IN-5 Related Antibodies

Top Publications Citing Use of Products

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COX COX-1 COX-2 COX-3

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5-LOX 12-LOX 15-LOX

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities[1].

Molecular Weight

443.52

Formula

C25H21N3O3S
CAS No.
SMILES

COC1=CC=C(C=C1)NC(CSC2=N/C(C(N2C3=CC=CC=C3)=O)=C\C4=CC=CC=C4)=O
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Purity & Documentation
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COX-2/15-LOX-IN-5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2/15-LOX-IN-5443790-30-5COXLipoxygenaseNF-κBCyclooxygenaseLOXNuclear factor-κBNuclear factor-kappaB15-COXInhibitorLPSRAW 264.7Anti-inflammatoryinhibitorinhibit

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