2. Immunology/Inflammation
  3. COX
  4. COX-2-IN-34

COX-2-IN-34 (compound 8a) is a selective and orally active inhibitor of COX-2 , with an IC50 of 0.42 μM. COX-2-IN-34 has no gastric ulcer toxicity but has anti-inflammatory effects.

For research use only. We do not sell to patients.

COX-2-IN-34 Chemical Structure

COX-2-IN-34 Chemical Structure

CAS No. : 2788578-71-0

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Based on 1 publication(s) in Google Scholar

COX-2-IN-34 Related Antibodies

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Description

COX-2-IN-34 (compound 8a) is a selective and orally active inhibitor of COX-2 , with an IC50 of 0.42 μM. COX-2-IN-34 has no gastric ulcer toxicity but has anti-inflammatory effects[1].

IC50 & Target

COX-2

0.42 μM (IC50)

In Vitro

COX-2-IN-34 (compound 8a) (100 μM, 24 h) shows no obvious cytotoxicity to RAW264.7 cells[1].
Cox-2- IN -34 selectively inhibits the COX-1 and COX-2 activity with IC50 values of 34.86 and 0.42μM, respectively. The inhibition effect of COX-2-IN-34 (10 μM ) on COX-2 reaches 82%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

COX-2-IN-34 Related Antibodies
In Vivo

COX-2-IN-34 (compound 8a) (50 mg/kg for p.o., three days) shows no gastric ulceration in normal male rat model[1].
COX-2-IN-34 (50 mg/kg for s.c., three times) shows significant anti-inflammatory effects in the Carrageenan-induced rat paw edema assay model [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The Carrageenan-induced rat paw edema assay model[1]
Dosage: 50 mg/kg
Administration: Subcutaneous injection (s.c.)
Result: Expressed the reduction of edema claw volume after 0h, 1 h, 2 h, 3h, 4 h, and 6 h of carrageenan injection compared to the control group.
Exhibited superior inhibition of 42.90% and 45.95% at the 3rd and 4th hour, respectively, which was comparatively much closer in potency to that of the Celecoxib (HY-14398) group (45.18% inhibition of edema at 3h).
Molecular Weight

245.23

Formula

C13H11NO4
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

O=C(NC1=CC=CC=C1O)C2=CC=CC(O)=C2O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (101.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0778 mL 20.3890 mL 40.7780 mL
5 mM 0.8156 mL 4.0778 mL 8.1556 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0778 mL 20.3890 mL 40.7780 mL 101.9451 mL
5 mM 0.8156 mL 4.0778 mL 8.1556 mL 20.3890 mL
10 mM 0.4078 mL 2.0389 mL 4.0778 mL 10.1945 mL
15 mM 0.2719 mL 1.3593 mL 2.7185 mL 6.7963 mL
20 mM 0.2039 mL 1.0195 mL 2.0389 mL 5.0973 mL
25 mM 0.1631 mL 0.8156 mL 1.6311 mL 4.0778 mL
30 mM 0.1359 mL 0.6796 mL 1.3593 mL 3.3982 mL
40 mM 0.1019 mL 0.5097 mL 1.0195 mL 2.5486 mL
50 mM 0.0816 mL 0.4078 mL 0.8156 mL 2.0389 mL
60 mM 0.0680 mL 0.3398 mL 0.6796 mL 1.6991 mL
80 mM 0.0510 mL 0.2549 mL 0.5097 mL 1.2743 mL
100 mM 0.0408 mL 0.2039 mL 0.4078 mL 1.0195 mL
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COX-2-IN-34 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-342788578-71-0COXCyclooxygenaseRAW 264.7rat paw edema assay modelInhibitorinhibitorinhibit

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