1. PI3K/Akt/mTOR Immunology/Inflammation
  2. PI3K COX
  3. COX-2/PI3K-IN-1

COX-2/PI3K-IN-1 (compound 5d) is a potent PI3K inhibitor with IC50 value of 1.14 nM. COX-2/PI3K-IN-1 is a selective COX-2 inhibitor with Ki value of 3.24 nM. COX-2/PI3K-IN-1 has anti-inflammatory and anti-cancer properties.

For research use only. We do not sell to patients.

COX-2/PI3K-IN-1 Chemical Structure

COX-2/PI3K-IN-1 Chemical Structure

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Description

COX-2/PI3K-IN-1 (compound 5d) is a potent PI3K inhibitor with IC50 value of 1.14 nM. COX-2/PI3K-IN-1 is a selective COX-2 inhibitor with Ki value of 3.24 nM. COX-2/PI3K-IN-1 has anti-inflammatory and anti-cancer properties.

IC50 & Target[1]

PI3K

1.14 nM (IC50)

COX-2

3.24 nM (Ki)

In Vitro

COX-2/PI3K-IN-1 (compound 5d) (50-500 µg/mL, 72 hours) exerts potent antitumor activities against Breast cancer (MCF-7) cells[1].
COX-2/PI3K-IN-1 (compound 5d) (10-150 µg/mL) has antioxidant properties with H2O2 scavenging activity equivalent to ascorbic acid and higher lysozyme inhibition(IC50=3.98 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: Breast cancer (MCF-7) cells and normal breast epithelial (MCF-10A) cells
Concentration: 50–500 µg/mL
Incubation Time: 72 hours
Result: Caused 40 % cell death at 0.75 μM in MCF-7 cells.
Molecular Weight

411.93

Formula

C19H14ClN5S2

SMILES

S=C(/N=C1C(N(C2=CC=CC=C2Cl)C3=C\1C=CC=C3)=S)NCN4C=CN=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
COX-2/PI3K-IN-1
Cat. No.:
HY-147911
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