COX-2/PI3K-IN-1 

COX-2/PI3K-IN-1 (compound 5d) is a potent PI3K inhibitor with IC₅₀ value of 1.14 nM. COX-2/PI3K-IN-1 is a selective COX-2 inhibitor with K_i value of 3.24 nM. COX-2/PI3K-IN-1 has anti-inflammatory and anti-cancer properties.

COX-2/PI3K-IN-1 (compound 5d) (50-500 µg/mL, 72 hours) exerts potent antitumor activities against Breast cancer (MCF-7) cells^[1].
COX-2/PI3K-IN-1 (compound 5d) (10-150 µg/mL) has antioxidant properties with H_{2O2 scavenging activity equivalent to ascorbic acid and higher lysozyme inhibition(IC50=3.98 nM)^[1].}

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

411.93

C₁₉H₁₄ClN₅S₂

S=C(/N=C1C(N(C2=CC=CC=C2Cl)C3=C\1C=CC=C3)=S)NCN4C=CN=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rajesh Kumar M, et al. p-TSA.H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer. Bioorg Chem. 2020 Sep;102:104046.  [Content Brief]