2. Protein Tyrosine Kinase/RTK
  3. VEGFR FGFR
  4. CP-547632 TFA

CP-547632 TFA is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 TFA is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs). CP-547632 TFA has antitumor efficacy.

For research use only. We do not sell to patients.

CP-547632 TFA Chemical Structure

CP-547632 TFA Chemical Structure

CAS No. : 2805804-54-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 121 Ask For Quote & Lead Time
Solution
10 mM * 1 mL in DMSO USD 121 Ask For Quote & Lead Time
Solid
5 mg USD 85 Ask For Quote & Lead Time
10 mg USD 125 Ask For Quote & Lead Time
25 mg USD 220 Ask For Quote & Lead Time
50 mg USD 310 Ask For Quote & Lead Time
100 mg USD 435 Ask For Quote & Lead Time

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Other Forms of CP-547632 TFA:

CP-547632 TFA Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CP-547632 TFA

View All VEGFR Isoform Specific Products:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CP-547632 TFA is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 TFA is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs). CP-547632 TFA has antitumor efficacy[1].

IC50 & Target[1]

VEGFR2

11 nM (IC50)

FGFR

9 nM (IC50)

In Vitro

CP-547632 TFA (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion, with an IC50 value of 6 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CP-547632 TFA Related Antibodies

Western Blot Analysis[1]

Cell Line: Serum-deprived cells
Concentration: 1, 4, 16, 63, 250, 1000 nM
Incubation Time: 1 hours
Result: Inhibited VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion.
In Vivo

CP-547632 TFA (p.o.; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts[1].
CP-547632 TFA (oral; 50 mg/kg; a single oral dose) yieldes plasma concentrations above 500 ng/ml for 12 hours[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic female mice (CD-1 nu/nu) bearing tumors (75-150 mm in size)[1]
Dosage: 6.25, 12.5, 25, 50, 100 mg/kg
Administration: PO; daily; 10-24 days
Result: Caused a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts.
Animal Model: Female athymic mice bearing H-Ras tumor[1]
Dosage: 50 mg/kg
Administration: Oral
Result: A single oral dose of 50 mg/kg yielded plasma concentrations above 500 ng/ml for 12 hours.
Molecular Weight

646.43

Formula

C22H25BrF5N5O5S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

FC(F)(C(O)=O)F.O=C(NC1=C(C(N)=O)C(OCC2=C(F)C=C(Br)C=C2F)=NS1)NCCCCN3CCCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (232.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5470 mL 7.7348 mL 15.4696 mL
5 mM 0.3094 mL 1.5470 mL 3.0939 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.42%

COA (254 KB) HNMR (297 KB) LCMS (121 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5470 mL 7.7348 mL 15.4696 mL 38.6739 mL
5 mM 0.3094 mL 1.5470 mL 3.0939 mL 7.7348 mL
10 mM 0.1547 mL 0.7735 mL 1.5470 mL 3.8674 mL
15 mM 0.1031 mL 0.5157 mL 1.0313 mL 2.5783 mL
20 mM 0.0773 mL 0.3867 mL 0.7735 mL 1.9337 mL
25 mM 0.0619 mL 0.3094 mL 0.6188 mL 1.5470 mL
30 mM 0.0516 mL 0.2578 mL 0.5157 mL 1.2891 mL
40 mM 0.0387 mL 0.1934 mL 0.3867 mL 0.9668 mL
50 mM 0.0309 mL 0.1547 mL 0.3094 mL 0.7735 mL
60 mM 0.0258 mL 0.1289 mL 0.2578 mL 0.6446 mL
80 mM 0.0193 mL 0.0967 mL 0.1934 mL 0.4834 mL
100 mM 0.0155 mL 0.0773 mL 0.1547 mL 0.3867 mL
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CP-547632 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-5476322805804-54-8CP547632CP 547632VEGFRFGFRVascular endothelial growth factor receptorFibroblast growth factor receptororallyATP-competitiveEGFRPDGFRβTKsantitumorVEGFR-2phosphorylationColo-205DLD-1MDA-MB-231Inhibitorinhibitorinhibit

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