2. Protein Tyrosine Kinase/RTK Apoptosis PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt JAK/STAT Signaling
  3. c-Fms Apoptosis Akt ERK STAT
  4. CSF1R-IN-26

CSF1R-IN-26 (Compound III-1) is the inhibitor for CSF-1R with an IC50 of 20.07 nM. CSF1R-IN-26 promotes the polarization of M2 macrophages to M1 macrophages, thereby inducing apoptosis in MC-38 cancer cell. CSF1R-IN-26 inhibits the activation of AKT/ERK/STAT3 signaling pathway. CSF1R-IN-26 reconstructs the tumor immune microenvironment and exhibits antitumor activity in mouse models. CSF1R-IN-26 exhibits pharmacokinetics characteristics in SD rats with a half-life 1.86 hours, and an oral bioavailability of 79.22%.

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CSF1R-IN-26 Chemical Structure

CSF1R-IN-26 Chemical Structure

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CSF1R-IN-26 Related Antibodies

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Description

CSF1R-IN-26 (Compound III-1) is the inhibitor for CSF-1R with an IC50 of 20.07 nM. CSF1R-IN-26 promotes the polarization of M2 macrophages to M1 macrophages, thereby inducing apoptosis in MC-38 cancer cell. CSF1R-IN-26 inhibits the activation of AKT/ERK/STAT3 signaling pathway. CSF1R-IN-26 reconstructs the tumor immune microenvironment and exhibits antitumor activity in mouse models. CSF1R-IN-26 exhibits pharmacokinetics characteristics in SD rats with a half-life 1.86 hours, and an oral bioavailability of 79.22%[1].

IC50 & Target

IC50: CSF-1R (20.07 nM)
Molecular Weight

415.87

Formula

C20H22ClN5O3
SMILES

CC1=NC(NC(N[C@H]2[C@@H](CCCC2)O)=O)=CC=C1OC3=CNC4=C3C=C(C=N4)Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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CSF1R-IN-26 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CSF1R-IN-26c-FmsApoptosisAktERKSTATCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RPKBProtein kinase BExtracellular signal regulated kinasesMC-38C57BL/6 mouseTAMimmunosuppressiveInhibitorinhibitorinhibit

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