2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. CTP Synthetase-IN-1

CTP Synthetase-IN-1 is a potent, orally active cytidine 5'-triphosphate synthetase (CTPS) inhibitor with IC50s of 32 nM and 18 nM for human CTPS1 and human CTPS2, respectively. CTP Synthetase-IN-1 has anti-inflammatory effects.

For research use only. We do not sell to patients.

CTP Synthetase-IN-1 Chemical Structure

CTP Synthetase-IN-1 Chemical Structure

CAS No. : 2338811-71-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 209 In-stock
Solution
10 mM * 1 mL in DMSO USD 209 In-stock
Solid
5 mg USD 185 In-stock
10 mg USD 310 In-stock
25 mg USD 640 In-stock
50 mg USD 1080 In-stock
100 mg USD 1850 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

CTP Synthetase-IN-1 Related Antibodies

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Description

CTP Synthetase-IN-1 is a potent, orally active cytidine 5'-triphosphate synthetase (CTPS) inhibitor with IC50s of 32 nM and 18 nM for human CTPS1 and human CTPS2, respectively. CTP Synthetase-IN-1 has anti-inflammatory effects[1].

IC50 & Target

IC50: 32 nM (human CTPS1) and 18 nM (human CTPS2)[1]
In Vitro

CTP Synthetase-IN-1 (compound 27) inhibits rat CTPS1, rat CTPS2, mouse CTPS1, and mouse CTPS2 with IC50 values of 27 nM, 23 nM, 26 nM, and 33 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CTP Synthetase-IN-1 Related Antibodies
In Vivo

CTP Synthetase-IN-1 (compound 27; 10-50 mg/kg; p.o; twice daily; for 18 days) shows significant pharmacological responses in collagen-induced arthritis (CIA) model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse collagen-induced arthritis (CIA) model[1]
Dosage: 10 mg/kg and 50 mg/kg
Administration: p.o; twice daily; for 18 days
Result: Resulted in improvements in specific indicators of disease severity.
Molecular Weight

512.53

Formula

C20H19F3N6O3S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C)(C)C1=CSC(NS(=O)(C2CC2)=O)=N1)NC3=NC=C(C4=NC(C(F)(F)F)=CN=C4)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (195.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9511 mL 9.7555 mL 19.5111 mL
5 mM 0.3902 mL 1.9511 mL 3.9022 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.56%

COA (252 KB) HNMR (296 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9511 mL 9.7555 mL 19.5111 mL 48.7776 mL
5 mM 0.3902 mL 1.9511 mL 3.9022 mL 9.7555 mL
10 mM 0.1951 mL 0.9756 mL 1.9511 mL 4.8778 mL
15 mM 0.1301 mL 0.6504 mL 1.3007 mL 3.2518 mL
20 mM 0.0976 mL 0.4878 mL 0.9756 mL 2.4389 mL
25 mM 0.0780 mL 0.3902 mL 0.7804 mL 1.9511 mL
30 mM 0.0650 mL 0.3252 mL 0.6504 mL 1.6259 mL
40 mM 0.0488 mL 0.2439 mL 0.4878 mL 1.2194 mL
50 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9756 mL
60 mM 0.0325 mL 0.1626 mL 0.3252 mL 0.8130 mL
80 mM 0.0244 mL 0.1219 mL 0.2439 mL 0.6097 mL
100 mM 0.0195 mL 0.0976 mL 0.1951 mL 0.4878 mL
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CTP Synthetase-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CTP Synthetase-IN-12338811-71-3DNA/RNA Synthesiscytidine 5'-triphosphate synthetaseCTPS2CTPS1anti-inflammatory effectsorally activeInhibitorinhibitorinhibit

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