2. Immunology/Inflammation
  3. Interleukin Related
  4. CTX-471

CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with Kd values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer.

For research use only. We do not sell to patients.

CTX-471 Chemical Structure

CTX-471 Chemical Structure

CAS No. : 2377152-49-1

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10 mg USD 2240 In-stock
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CTX-471 Related Antibodies

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Description

CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with Kd values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer[1].

Species

Human
IC50 & Target

Kd for CD137: 50 nM (human); 61 nM (cynomolgus macaque); 748 nM (mouse)[1]
In Vitro

CTX-471 (5-500 nM) has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with Kd values of 50 nM, 61 nM and 748 nM, respectively[1].
CTX-471 binds to a unique epitope on CD137[1].
CTX-471 (0.1-100 nM; 1, 10 μg/mL; 3 days) increases IFN-y production by human T cells in an Fcy receptor-dependent (FcyR-dependent) manner in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CTX-471 Related Antibodies
In Vivo

CTX-471 (i.p.; 150 μg) exhibits curative monotherapy activity in various syngeneic tumor models and shows a unique ability to cure mice of very large tumors. CTX-471 (i.v.; 10-80 mg/kg; on days 0, 7, 14, and 21) is well tolerated, with no signs of hepatic toxicity in high doses.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[1]
Dosage: 150 μg;
10-80 mg/kg
Administration: i.p., on days 6, 9, 12, 19 and 26( or on days 7, 10, 13, 20, and 27 or on days 0, 3, 6, and 9);
i.v., on days 0, 7, 14, and 21
Result: Required T and NK cells, as well as FcγR engagement to achieve its efficacy.
Do not induce hepatic inflammation.
Clinical Trial
Formula

CT
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[3H][C][X471]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CTX-471 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CTX-4712377152-49-1CTX471CTX 471Interleukin RelatedILTNF receptor superfamily (TNFRSF)Cell surface glycoprotein CD137immune receptorstumormonoclonal antibodyimmunomodulationInhibitorinhibitorinhibit

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