2. Apoptosis
  3. Apoptosis TNF Receptor
  4. Cusatuzumab

Cusatuzumab  (Synonyms: ARGX-110)

Cat. No.: HY-P99014 Purity: 98.80%
Data Sheet
SDS
COA
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Cusatuzumab (ARGX-110) is a human αCD70 monoclonal antibody. Cusatuzumab has the activity of enhancied antibody-dependent cellular cytotoxicity (ADCC). Cusatuzumab blocks the CD70/CD27 signaling pathway, reduces leukemia stem cells (LSCs) and triggers gene signatures related to myeloid differentiation and apoptosis. Cusatuzumab can be used to study leukemia.

For research use only. We do not sell to patients.

CAS No. : 1864871-20-4

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Based on 1 publication(s) in Google Scholar

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Cusatuzumab Related Antibodies

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1 Publications Citing Use of MCE Cusatuzumab

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

Cusatuzumab (ARGX-110) is a human αCD70 monoclonal antibody. Cusatuzumab has the activity of enhancied antibody-dependent cellular cytotoxicity (ADCC). Cusatuzumab blocks the CD70/CD27 signaling pathway, reduces leukemia stem cells (LSCs) and triggers gene signatures related to myeloid differentiation and apoptosis. Cusatuzumab can be used to study leukemia[1].

In Vitro

Cusatuzumab (10 μg/mL; 14 days) can inhibit colony formation of leukemia stem cells in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cusatuzumab Related Antibodies
In Vivo

Cusatuzumab (intraperitoneal injection; 10 mg/kg; 3 times) can reduce leukemia cell colonization and LSC number, and the effect is better in the presence of NK cells in NSG mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Patient bone marrow cells treated sublethally irradiated NSG mice[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.); 3 times within a week
Result: Was similarly effective in reducing leukemia cell engraftment and LSC numbers as the blocking αCD70 mAb in the absence of NK cells.
Further reduced leukemia engraftment and LSC numbers in the bone marrow and spleen in the presence of NK cells.
Clinical Trial
NCT NumberSponsorConditionStart DatePhase
NCT04023526OncoVerity, Inc.|argenx|Janssen Research & Development, LLC
Leukemia, Myeloid, Acute
July 29, 2019Phase 2
NCT04150887OncoVerity, Inc.|argenx|Janssen Research & Development, LLC
Leukemia, Myeloid, Acute
December 23, 2019Phase 1
NCT04241549OncoVerity, Inc.|argenx|Janssen Pharmaceutical K.K.
Leukemia, Myeloid, Acute
March 25, 2020Phase 1
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Cusatuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
Purity & Documentation

Purity: 98.80%

Data Sheet (259 KB) SDS (251 KB)

COA (231 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Cusatuzumab Related Classifications

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Keywords:

Cusatuzumab1864871-20-4ARGX-110ARGX110ARGX 110ApoptosisTNF ReceptorTumor Necrosis Factor ReceptorTNFReukemia stem cells (LSCs)Inhibitorinhibitorinhibit

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