2. GPCR/G Protein
  3. Platelet-activating Factor Receptor (PAFR)
  4. CV-6209

CV-6209 is a potent antagonist of platelet activating factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC50s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats.

For research use only. We do not sell to patients.

CV-6209 Chemical Structure

CV-6209 Chemical Structure

CAS No. : 100488-87-7

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5 mg USD 690 In-stock
10 mg USD 1100 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of CV-6209:

CV-6209 Related Antibodies

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Description

CV-6209 is a potent antagonist of platelet activating factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC50s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats[1].

IC50 & Target

platelet activating factor (PAF)[1]
In Vitro

CV-6209 inhibits [3H]serotonin release from rabbit platelets stimulated with PAF (30 nM)[1].
CV-6209 has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen[1].
CV-6209 (0.2-2 μM; pretreated for 30 min) inhibits PAF-induced MC degranulation in both LAD2 and hLMCs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CV-6209 Related Antibodies
In Vivo

CV-6209 (i.v.) inhibits PAF (0.3 μg/kg; i.v.)-induced hypotension in rats (ED50=0.009 mg/kg) with no effect on the hypotension induced by arachidonic acid, histamine, bradykinin and isoproterenol[1].
CV-6209 (66 μg; i.v.) reduces asparaginase-induced hypersensitivity compared with nonpretreated, sensitized mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

642.31

Formula

C34H60ClN3O6
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC[N+]1=CC=CC=C1CN(C(C)=O)C(OCC(OC)COC(NCCCCCCCCCCCCCCCCCC)=O)=O.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (155.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5569 mL 7.7844 mL 15.5688 mL
5 mM 0.3114 mL 1.5569 mL 3.1138 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (241 KB) HNMR (132 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5569 mL 7.7844 mL 15.5688 mL 38.9220 mL
5 mM 0.3114 mL 1.5569 mL 3.1138 mL 7.7844 mL
10 mM 0.1557 mL 0.7784 mL 1.5569 mL 3.8922 mL
15 mM 0.1038 mL 0.5190 mL 1.0379 mL 2.5948 mL
20 mM 0.0778 mL 0.3892 mL 0.7784 mL 1.9461 mL
25 mM 0.0623 mL 0.3114 mL 0.6228 mL 1.5569 mL
30 mM 0.0519 mL 0.2595 mL 0.5190 mL 1.2974 mL
40 mM 0.0389 mL 0.1946 mL 0.3892 mL 0.9731 mL
50 mM 0.0311 mL 0.1557 mL 0.3114 mL 0.7784 mL
60 mM 0.0259 mL 0.1297 mL 0.2595 mL 0.6487 mL
80 mM 0.0195 mL 0.0973 mL 0.1946 mL 0.4865 mL
100 mM 0.0156 mL 0.0778 mL 0.1557 mL 0.3892 mL
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CV-6209 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CV-6209100488-87-7CV6209CV 6209Platelet-activating Factor Receptor (PAFR)plateletactivatingfactorPAFaggregationplateletshypotensionInhibitorinhibitorinhibit

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