2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. CXCR4 modulator-2

CXCR4 modulator-2 (compound Z7R) is a highly potent CXCR4 modulator with an IC50 value of 1.25 nM. CXCR4 modulator-2 has acceptable stability (t1/2 = 77.1 min) in mouse serum and exhibits anti-inflammatory activity in mouse edema model.

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CXCR4 modulator-2 Chemical Structure

CXCR4 modulator-2 Chemical Structure

CAS No. : 2488943-55-9

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CXCR4 modulator-2 Related Antibodies

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Description

CXCR4 modulator-2 (compound Z7R) is a highly potent CXCR4 modulator with an IC50 value of 1.25 nM. CXCR4 modulator-2 has acceptable stability (t1/2 = 77.1 min) in mouse serum and exhibits anti-inflammatory activity in mouse edema model[1].

IC50 & Target[1]

CXCR4

1.25 nM (IC50)

In Vivo

CXCR4 modulator-2 (10 mg/kg; IP; single dosage) significantly reduces the edema weights (∼50%) in the lesion and decreases the expression of CXCR4s[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male nude mice (6 weeks, 20 g; subcutaneous injection of 50 μL of λ-carrageenan)[1]
Dosage: 10 mg/kg
Administration: IP; single dosage
Result: Significantly reduced the edema weights (∼50%) in the lesion and decreased the expression of CXCR4s.
Molecular Weight

428.53

Formula

C21H32N8O2
CAS No.
SMILES

O=C(NC1CCN(C(CCN2C=CC3=C2C=NC=C3)=O)CC1)[C@H](N)CCCNC(N)=N
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Purity & Documentation
References
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CXCR4 modulator-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CXCR4 modulator-22488943-55-9CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsAnti-inflammatoryEdema modelNude miceλ-carrageenanInhibitorinhibitorinhibit

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CXCR4 modulator-2
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