2. GPCR/G Protein
  3. Amylin Receptor
  4. Cyclic AC253

Cyclic AC253 is an antagonist for amylin receptor, with IC50 of 0.3 μM. Cyclic AC253 exhibits neuroprotective efficacy against Aβ toxicity and abrogates Aβ-induced impairment of hippocampal long-term potentiation. Cyclic AC253 penetrate blood-brain barrier (BBB).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclic AC253 Chemical Structure

Cyclic AC253 Chemical Structure

Size Price Stock Quantity
1 mg USD 150 In-stock
5 mg USD 370 In-stock
10 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

Cyclic AC253 Related Antibodies

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Description

Cyclic AC253 is an antagonist for amylin receptor, with IC50 of 0.3 μM. Cyclic AC253 exhibits neuroprotective efficacy against Aβ toxicity and abrogates Aβ-induced impairment of hippocampal long-term potentiation. Cyclic AC253 penetrate blood-brain barrier (BBB)[1].

In Vitro

Cyclic AC253 (0-10 μM) protects neuronal cells HFNs and N2a from Aβ1–42-induced cytotoxicity and apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclic AC253 Related Antibodies
In Vivo

Cyclic AC253 (200 μg/kg, ip, 3 times a week for 10 weeks) improves cognitive deficits in TgCRND8 mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Alzheimer’s Disease in TgCRND8 mice model[1]
Dosage: 200 μg/kg
Administration: ip, 3 times a week for 10 weeks
Result: Improved cognitive deficits.
Molecular Weight

3009.34

Formula

C126H202N42O40S2
Appearance

Solid

Color

White to off-white

Sequence

Phe-Leu-Pro-Leu-Leu-Ile-Leu-Gly-Ser-Leu-Leu-Met-Thr-Pro-Pro-Val-Ile-Gln-Ala-Ile-His-Asp-Ala-Gln-Arg-NH2 (Disulfide bridge: Cys1-Cys26)
Sequence Shortening

CLGRLSQELHRLQTYPRTNTGSNTYC-NH2 (Disulfide bridge: Cys1-Cys26)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (33.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3323 mL 1.6615 mL 3.3230 mL
5 mM 0.0665 mL 0.3323 mL 0.6646 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3323 mL 1.6615 mL 3.3230 mL 8.3075 mL
5 mM 0.0665 mL 0.3323 mL 0.6646 mL 1.6615 mL
10 mM 0.0332 mL 0.1661 mL 0.3323 mL 0.8307 mL
15 mM 0.0222 mL 0.1108 mL 0.2215 mL 0.5538 mL
20 mM 0.0166 mL 0.0831 mL 0.1661 mL 0.4154 mL
25 mM 0.0133 mL 0.0665 mL 0.1329 mL 0.3323 mL
30 mM 0.0111 mL 0.0554 mL 0.1108 mL 0.2769 mL
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Cyclic AC253 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclic AC253Cyclic AC 253Cyclic AC-253Amylin ReceptorAMYRAlzheimer's DiseaseTgCRND8 miceBBB penetrateHEK29Inhibitorinhibitorinhibit

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