Cyclo(Arg-Gly-Asp-D-Phe-Val) (Synonyms: Cyclo(RGDfV); C(RGDfV))

Cat. No.: HY-P1613: FAQs
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Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia.

For research use only. We do not sell to patients.

Cyclo(Arg-Gly-Asp-D-Phe-Val) Chemical Structure

CAS No. : 137813-35-5

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Other In-stock Forms of Cyclo(Arg-Gly-Asp-D-Phe-Val):

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA

Other Forms of Cyclo(Arg-Gly-Asp-D-Phe-Val):

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA In-stock

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•Related Small Molecules:

•Related Proteins:

View All Integrin Isoform Specific Products:

View All Isoforms

αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

αvβ3^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.25 x 10^-1 μM Compound: 6, c(RGDfV)	Displacement of [125I]echistatin from human integrin alpha5beta3 expressed in human A549 cells by binding assay Displacement of [125I]echistatin from human integrin alpha5beta3 expressed in human A549 cells by binding assay	[PMID: 21349709]
HUVEC	IC₅₀	0.53 μM Compound: CycloRGDfV	Inhibition of HUVEC migration after 4 hrs Inhibition of HUVEC migration after 4 hrs	[PMID: 19081719]
HUVEC	IC₅₀	3.1 μM Compound: CycloRGDfV	Inhibition of FGF-induced HUVEC proliferation after 48 hrs Inhibition of FGF-induced HUVEC proliferation after 48 hrs	[PMID: 19081719]
HUVEC	IC₅₀	4.5 μM Compound: CycloRGDfV	Inhibition of VEGF-induced HUVEC proliferation after 48 hrs Inhibition of VEGF-induced HUVEC proliferation after 48 hrs	[PMID: 19081719]
HUVEC	IC₅₀	9.6 μM Compound: c[RGDfV]	Inhibition of alphavbeta3 integrin-mediated cell adhesion in HUVEC on vitronectin coated plate after 30 mins Inhibition of alphavbeta3 integrin-mediated cell adhesion in HUVEC on vitronectin coated plate after 30 mins	[PMID: 20055426]
K562	IC₅₀	34.7 μM Compound: cyclo-Arg-Gly-Asp-D-Phe-Val	Antagonist activity at alpha5beta1 integrin in human K562 cells assessed as inhibition of fibronectin-mediated cell adhesion after 30 mins by fluorescence assay Antagonist activity at alpha5beta1 integrin in human K562 cells assessed as inhibition of fibronectin-mediated cell adhesion after 30 mins by fluorescence assay	[PMID: 24973662]
K562	IC₅₀	34.7 μM Compound: c[RGDfV]	Inhibition of alpha5beta1 integrin-mediated cell adhesion in human K562 cells on fibronectin coated plate after 30 mins Inhibition of alpha5beta1 integrin-mediated cell adhesion in human K562 cells on fibronectin coated plate after 30 mins	[PMID: 20055426]
WM-115	IC₅₀	0.5 μM Compound: c-(-Arg-Gly-Asp-D-Phe-Val-)	Binding affinity to integrin in human WM-115 cells after 30 mins by immobilized vitronectin-based competitive cell adhesion assay Binding affinity to integrin in human WM-115 cells after 30 mins by immobilized vitronectin-based competitive cell adhesion assay	[PMID: 23387527]

In Vitro

Cyclo(Arg-Gly-Asp-d-Phe-Val) (Cyclo(RGDfV)) (35 nM, 4-24 h) disruptes the adhesion and migration between the tumor cells and the matrix, induces the leukemia cells to leave the protective microenvironment and increases their sensitivity to cell cycle-dependent agents^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:	MV4–11 cells
Concentration:	35 nM
Incubation Time:	24 h
Result:	Affected the leukemia cell cycle, decreased the G0/G1 phase of leukemia cells in the 3D and 2D culture systems and increased the S phase of leukemia cells in the 3D and 2D culture systems.

Apoptosis Analysis^[1]

Cell Line:	MV4–11 cells
Concentration:	35 nM
Incubation Time:	24 h
Result:	Increased the apoptosis rates.

Molecular Weight

574.63

Formula

C₂₆H₃₈N₈O₇

CAS No.

137813-35-5

Sequence Shortening

Cyclo(RGD-{d-Phe}-V)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shen ZH, et al. Targeting of the leukemia microenvironment by c(RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12(5):3278-3284. [Content Brief]

Cyclo(Arg-Gly-Asp-D-Phe-Val) Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(Arg-Gly-Asp-D-Phe-Val)137813-35-5Cyclo(RGDfV) C(RGDfV)IntegrinApoptosisintegrin αvβ3antitumoracute myeloid leukemiacancerInhibitorinhibitorinhibit

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