2. Cytoskeleton Apoptosis
  3. Integrin Apoptosis
  4. Cyclo(Arg-Gly-Asp-D-Phe-Val)

Cyclo(Arg-Gly-Asp-D-Phe-Val)  (Synonyms: Cyclo(RGDfV); C(RGDfV))

Cat. No.: HY-P1613
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Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclo(Arg-Gly-Asp-D-Phe-Val) Chemical Structure

Cyclo(Arg-Gly-Asp-D-Phe-Val) Chemical Structure

CAS No. : 137813-35-5

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Cyclo(Arg-Gly-Asp-D-Phe-Val) Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia[1].

IC50 & Target

αvβ3[1]
In Vitro

Cyclo(Arg-Gly-Asp-d-Phe-Val) (Cyclo(RGDfV)) (35 nM, 4-24 h) disruptes the adhesion and migration between the tumor cells and the matrix, induces the leukemia cells to leave the protective microenvironment and increases their sensitivity to cell cycle-dependent agents[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclo(Arg-Gly-Asp-D-Phe-Val) Related Antibodies

Cell Cycle Analysis[1]

Cell Line: MV4–11 cells
Concentration: 35 nM
Incubation Time: 24 h
Result: Affected the leukemia cell cycle, decreased the G0/G1 phase of leukemia cells in the 3D and 2D culture systems and increased the S phase of leukemia cells in the 3D and 2D culture systems.

Apoptosis Analysis[1]

Cell Line: MV4–11 cells
Concentration: 35 nM
Incubation Time: 24 h
Result: Increased the apoptosis rates.
Molecular Weight

574.63

Formula

C26H38N8O7
CAS No.
Sequence Shortening

Cyclo(RGD-{d-Phe}-V)
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cyclo(Arg-Gly-Asp-D-Phe-Val) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(Arg-Gly-Asp-D-Phe-Val)137813-35-5Cyclo(RGDfV) C(RGDfV)IntegrinApoptosisintegrin αvβ3antitumoracute myeloid leukemiacancerInhibitorinhibitorinhibit

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