2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Cyclopentolate hydrochloride

Cyclopentolate hydrochloride  (Synonyms: DL-Cyclopentolate hydrochloride)

Cat. No.: HY-B1621A Purity: 99.93%
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Cyclopentolate (DL-Cyclopentolate) hydrochloride is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle). Cyclopentolate hydrochloride is an anti-muscarinic agent commonly used in the ophthalmologic practice.

For research use only. We do not sell to patients.

Cyclopentolate hydrochloride Chemical Structure

Cyclopentolate hydrochloride Chemical Structure

CAS No. : 5870-29-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 44 In-stock
Solution
10 mM * 1 mL in DMSO USD 44 In-stock
Solid
5 mg USD 25 In-stock
10 mg USD 40 In-stock
25 mg USD 80 In-stock
50 mg USD 130 In-stock
100 mg USD 210 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Cyclopentolate hydrochloride:

Cyclopentolate hydrochloride Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cyclopentolate (DL-Cyclopentolate) hydrochloride is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle). Cyclopentolate hydrochloride is an anti-muscarinic agent commonly used in the ophthalmologic practice[1][2].

In Vivo

Survival in rats pretreated with cyclopentolate (20 mg/kg) is 90%[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eighty Sprague-Dawley rats (acute, lethal organophosphate pesticide (OP) poisoning model)[3]
Dosage: 20 mg/kg (Ophthalmic cyclopentolate)
Administration: i.p.
Result: Survival in rats pretreated with ophthalmic cyclopentolate (20 mg/kg) is 90%.
Clinical Trial
Molecular Weight

327.85

Formula

C17H26ClNO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCCN(C)C)C(C1(O)CCCC1)C2=CC=CC=C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (762.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (305.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0502 mL 15.2509 mL 30.5018 mL
5 mM 0.6100 mL 3.0502 mL 6.1004 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (305.02 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.0502 mL 15.2509 mL 30.5018 mL 76.2544 mL
5 mM 0.6100 mL 3.0502 mL 6.1004 mL 15.2509 mL
10 mM 0.3050 mL 1.5251 mL 3.0502 mL 7.6254 mL
15 mM 0.2033 mL 1.0167 mL 2.0335 mL 5.0836 mL
20 mM 0.1525 mL 0.7625 mL 1.5251 mL 3.8127 mL
25 mM 0.1220 mL 0.6100 mL 1.2201 mL 3.0502 mL
30 mM 0.1017 mL 0.5084 mL 1.0167 mL 2.5418 mL
40 mM 0.0763 mL 0.3813 mL 0.7625 mL 1.9064 mL
50 mM 0.0610 mL 0.3050 mL 0.6100 mL 1.5251 mL
60 mM 0.0508 mL 0.2542 mL 0.5084 mL 1.2709 mL
80 mM 0.0381 mL 0.1906 mL 0.3813 mL 0.9532 mL
100 mM 0.0305 mL 0.1525 mL 0.3050 mL 0.7625 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cyclopentolate hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclopentolate5870-29-1DL-CyclopentolatemAChRMuscarinic acetylcholine receptorantimuscariniccycloplegicorganophosphatepesticidethicknesschoroidal ophthalmologicpracticeInhibitorinhibitorinhibit

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