2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. CYP3A4-IN-4

CYP3A4-IN-4 (compound Δ,Λ-3), a Ru(II)−Ir(III) Conjugate, is a photoactive inhibitor of the major human drug metabolizing enzyme CYP3A4. CYP3A4-IN-4 containing the [Ru(tpy)(Me2bpy)] photocaging group showed an IC50 of 2.2 μM for inhibition of microsomal CYP3A4 under light conditions (λirr=530 nm, tirr=15 min). CYP3A4-IN-4 shows the phototherapeutic index (PI) for of 5.4.

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CYP3A4-IN-4 Chemical Structure

CYP3A4-IN-4 Chemical Structure

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CYP3A4-IN-4 Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

CYP3A4-IN-4 (compound Δ,Λ-3), a Ru(II)−Ir(III) Conjugate, is a photoactive inhibitor of the major human drug metabolizing enzyme CYP3A4. CYP3A4-IN-4 containing the [Ru(tpy)(Me2bpy)] photocaging group showed an IC50 of 2.2 μM for inhibition of microsomal CYP3A4 under light conditions (λirr=530 nm, tirr=15 min). CYP3A4-IN-4 shows the phototherapeutic index (PI) for of 5.4[1].

IC50 & Targetytochrome P450

CYP3A4

 

Molecular Weight

1656.19

Formula

C80H61Cl3IrN11ORuS2
SMILES

O=C(CCC1=CC=[N]([Ru+2]23([N]4=C5C=CC=C4C6=CC=CC=[N]62)([N]7=C(C)C=CC=C7C8=CC=CC(C)=[N]83)[N]9=C5C=CC=C9)C=C1)NCC%10=C[N]%11=C(C%12=[N]([Ir+]%13%14(C%15=C(C%16=[N]%14C(C=CC=C%17)=C%17C=C%16)SC%18=C%15C=CC=C%18)%11C%19=C(C%20=[N]%13C(C=CC=C%21)=C%21C=C%20)SC%22=C%19C=CC=C%22)C=CC=C%12)C=C%10.[Cl-].[Cl-].[Cl-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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CYP3A4-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP3A4-IN-4Cytochrome P450CYPsRu(II)?Ir(III)photoactiveCYP3A4Ru(tpy)(Me2bpy)photocaging groupInhibitorinhibitorinhibit

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