2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. CYP4Z1-IN-1

CYP4Z1-IN-1 (compound 7c) is a potent CYP4Z1 inhibitor, with an IC50 of 41.8 nM. CYP4Z1-IN-1 decreases the expression of breast CSCs stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in a concentration-dependent manner in vitro and in vivo.

For research use only. We do not sell to patients.

CYP4Z1-IN-1 Chemical Structure

CYP4Z1-IN-1 Chemical Structure

CAS No. : 2760611-38-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

CYP4Z1-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CYP4Z1-IN-1 (compound 7c) is a potent CYP4Z1 inhibitor, with an IC50 of 41.8 nM. CYP4Z1-IN-1 decreases the expression of breast CSCs stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in a concentration-dependent manner in vitro and in vivo[1].

IC50 & Target

CYP4Z1

41.8 ± 1.4 nM (IC50)

CYP4F11

291.3 ± 46 nM (IC50)

CYP4F12

1598.3 ± 5 nM (IC50)

CYP2D6

>10 000 nM (IC50)

CYP2C9

>10 000 nM (IC50)

CYP3A4

>10 000 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
483 nM
Compound: 7c
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36414390]
MDA-MB-231 IC50
483 nM
Compound: 7c
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36414390]
In Vitro

CYP4Z1-IN-1 (compound 7c) shows antiproliferative activity against breast CSCs (cancer stem cells), with an IC50 of 483 ± 2.5 nM[1].
CYP4Z1-IN-1 (0.8-51.2 μM, 24 h) suppresses the expression of stemness markers (P-gp, Oct3/4, Nanog, ALDH1A1, and Sox2) in breast cancer cells[1].
CYP4Z1-IN-1 (0.8-51.2 μM, 24-48 h) attenuates the migration and invasion ability of breast cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CYP4Z1-IN-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: MCF-7 and MDA-MB-231 cells
Concentration: 0.8 μM, 3.2 μM, 12.8 μM, 51.2 μM
Incubation Time: 24 h
Result: Significantly suppressed the protein expression of stemness markers (P-gp, Oct3/4, Nanog, ALDH1A1, and Sox2) in MCF-7 cells in a concentration-dependent manner.
In Vivo

CYP4Z1-IN-1 (compound 7c) (2000 mg/kg, orally, for 7 days) shows no evident toxicity and body weight loss in mice[1].
CYP4Z1-IN-1 (MCF-7 and MDA-MB-231 cells (12.8 μM, 72 h) implanted in the inguinal mammary gland of mice subcutaneously) blocks the tumor-initiating ability of breast cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 2000 mg/kg
Administration: orally, for 7 days
Result: Showed that compound 7c was rather safe; no evident toxicity and body weight loss were observed.
Animal Model: BALB/c-nude mice (3-4 week old, female)[1]
Dosage: 12.8 μM
Administration: MCF-7 and MDA-MB-231 cells were pre-treated with 7c (12.8 μM) for 72 h and were then implanted in the inguinal mammary gland of mice subcutaneously
Result: Blocked the tumor-initiating ability of breast cancer cells.
Molecular Weight

250.29

Formula

C13H18N2O3
CAS No.
SMILES

O=C(CCCC1=CC=C(C=C1)N/C=N/O)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CYP4Z1-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP4Z1-IN-12760611-38-7Cytochrome P450CYPsCancer stem cellsCSCsMCF-7 cellsMDA-MB-231 cellsbreast cancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CYP4Z1-IN-1
Cat. No.:
HY-152159
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.