2. Anti-infection Immunology/Inflammation Metabolic Enzyme/Protease
  3. Fungal PD-1/PD-L1 Cytochrome P450
  4. CYP51/PD-L1-IN-2

CYP51/PD-L1-IN-2 (compound L20) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-2 is a dual inhibitor of CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-2 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death.

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CYP51/PD-L1-IN-2 Chemical Structure

CYP51/PD-L1-IN-2 Chemical Structure

CAS No. : 3032386-58-3

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CYP51/PD-L1-IN-2 Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

CYP51/PD-L1-IN-2 (compound L20) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-2 is a dual inhibitor of CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-2 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death[1].

IC50 & Target

IC50: 0.263 μM (CYP51), 0.017 μM (PD-L1)[1]
Molecular Weight

469.50

Formula

C25H23N7O3
CAS No.
SMILES

O=C(C1=NC2=CC=CC=C2C(N3C=NC=N3)=N1)NC4CCN(C(C5=CC=C(C(C)=O)C=C5)=O)CC4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CYP51/PD-L1-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP51/PD-L1-IN-23032386-58-3FungalPD-1/PD-L1Cytochrome P450PD-1/Programmed death-ligand 1CYPsmitochondrial damageROS aggregationfungal cleavagefungal deathInhibitorinhibitorinhibit

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