2. Anti-infection Apoptosis
  3. Antibiotic Bacterial Apoptosis Bcl-2 Family Caspase
  4. Cytochalasin H

Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity.

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Cytochalasin H Chemical Structure

Cytochalasin H Chemical Structure

CAS No. : 53760-19-3

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Cytochalasin H Related Antibodies

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Description

Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity[1][2][3].

In Vitro

Cytochalasin H (24-72 h) inhibits the proliferation of A549 cells with an IC50 value of 159.5 µM[1].
Cytochalasin H (0-50 µM; 48 h) induces apoptosis, arrests cell cycle at the G2/M phase and affects expression of apoptosis-related proteins in A549 cells[1].
Cytochalasin H (1-512 μg/mL) has antibacterial activity against MDR entero-pathogenic bacteria, Gram-positive bacterium, Staphylococcus aureus[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cytochalasin H Related Antibodies

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 0, 6.25, 12.5, 25 and 50 µM
Incubation Time: 48 h
Result: Induced apoptosis in a dose-dependent manner in the A549 cells.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 0, 6.25, 12.5, 25 and 50 µM
Incubation Time: 48 h
Result: Arrested cell cycle at the G2/M phase and sub-G1 peaks.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0, 6.25, 12.5, 25 and 50 µM
Incubation Time: 48 h
Result: Increased the protein expression levels of Bax, P53 and cleaved caspase-3 and decreased the protein expression levels of Bcl-xL, Bcl-2 and full-length caspase-3.
In Vivo

Cytochalasin H (2.5 mg/kg; i.p.) can delay the growth of A549 xenograft tumors in Balb/cnu/nu mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male Balb/cnu/nu mice with A549 xenograft[2]
Dosage: 2.5 mg/kg
Administration: intraperitoneal injection; 3 injections/week,for 80 days
Result: Attenuated tumor growth in vivo.
Molecular Weight

493.63

Formula

C30H39NO5
CAS No.
SMILES

O=C([C@@]12[C@](/C=C/C[C@H](C)C[C@@](C)(O)/C=C/[C@H]2OC(C)=O)([H])[C@@H]3O)N[C@@H](CC4=CC=CC=C4)[C@]1([H])[C@H](C)C3=C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cytochalasin H Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cytochalasin H53760-19-3AntibioticBacterialApoptosisBcl-2 FamilyCaspasenature productfungusPhomopsisanti-angiogenicbacterialA549 cellsInhibitorinhibitorinhibit

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