2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. [D-Arg25]-Neuropeptide Y (human)

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y1 receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

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[D-Arg25]-Neuropeptide Y (human) Chemical Structure

[D-Arg25]-Neuropeptide Y (human) Chemical Structure

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Other Forms of [D-Arg25]-Neuropeptide Y (human):

[D-Arg25]-Neuropeptide Y (human) Related Antibodies

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Description

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y1 receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity[1].
IC50 & Target

NPY Y1 receptor

 

In Vitro

[D-Arg25]-NPY (1 μM) reversibly hyperpolarizes the membrane potential of hypocretin cells by 9.9 ± 1.4 mV (data not shown; p < 0.01; n = 10[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[D-Arg25]-Neuropeptide Y (human) Related Antibodies
In Vivo

Intracerebroventricular (icv) administration of [D-Arg25]NPY stimulates food intake in freely-feeding rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

4271.68

Formula

C189H285N55O57S
Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-{d-Arg}-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
Sequence Shortening

YPSKPDNPGEDAPAEDMARYYSAL-{d-Arg}-HYINLITRQRY-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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[D-Arg25]-Neuropeptide Y (human) Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[D-Arg25]-Neuropeptide Y (human)Neuropeptide Y ReceptorNPY receptorAlzheimer'sdiseasecorticalβ-AmyloidfoodintakeInhibitorinhibitorinhibit

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