2. Epigenetics TGF-beta/Smad Metabolic Enzyme/Protease
  3. PKC Phosphatase Endogenous Metabolite
  4. D-erythro-Sphingosine-d7

D-erythro-Sphingosine-d7  (Synonyms: Erythrosphingosine-d7; erythro-C18-Sphingosine-d7; trans-4-Sphingenine-d7)

Cat. No.: HY-101047S Purity: 99.00%
SDS COA Handling Instructions

Molarity Calculator

D-erythro-Sphingosine-d7 is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

For research use only. We do not sell to patients.

D-erythro-Sphingosine-d<sub>7</sub> Chemical Structure

D-erythro-Sphingosine-d7 Chemical Structure

CAS No. : 1246304-34-6

Size Price Stock Quantity
500 μg In-stock

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of D-erythro-Sphingosine-d7:

D-erythro-Sphingosine-d7 Related Antibodies

Top Publications Citing Use of Products

View All PKC Isoform Specific Products:

View All Isoforms
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

D-erythro-Sphingosine-d7 is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-erythro-Sphingosine-d7 Related Antibodies
Molecular Weight

306.54

Formula

C18H30D7NO2
CAS No.
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])CCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (163.11 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2622 mL 16.3111 mL 32.6222 mL
5 mM 0.6524 mL 3.2622 mL 6.5244 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.00%

SDS (252 KB)

COA (241 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2622 mL 16.3111 mL 32.6222 mL 81.5554 mL
5 mM 0.6524 mL 3.2622 mL 6.5244 mL 16.3111 mL
10 mM 0.3262 mL 1.6311 mL 3.2622 mL 8.1555 mL
15 mM 0.2175 mL 1.0874 mL 2.1748 mL 5.4370 mL
20 mM 0.1631 mL 0.8156 mL 1.6311 mL 4.0778 mL
25 mM 0.1305 mL 0.6524 mL 1.3049 mL 3.2622 mL
30 mM 0.1087 mL 0.5437 mL 1.0874 mL 2.7185 mL
40 mM 0.0816 mL 0.4078 mL 0.8156 mL 2.0389 mL
50 mM 0.0652 mL 0.3262 mL 0.6524 mL 1.6311 mL
60 mM 0.0544 mL 0.2719 mL 0.5437 mL 1.3593 mL
80 mM 0.0408 mL 0.2039 mL 0.4078 mL 1.0194 mL
100 mM 0.0326 mL 0.1631 mL 0.3262 mL 0.8156 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

D-erythro-Sphingosine-d7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-erythro-Sphingosine-d71246304-34-6Erythrosphingosine-d7erythro-C18-Sphingosine-d7trans-4-Sphingenine-d7PKCPhosphataseEndogenous MetaboliteProtein kinase CInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
D-erythro-Sphingosine-d7
Cat. No.:
HY-101047S
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.