d-KLA Peptide  (Synonyms: D-(KLAKLAK)2)

d-KLA Peptide is a synthetic pro-apoptotic peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide activates biochemical pathways associated with apoptosis, including the activation of caspase family proteins and PARP (poly ADP ribose polymerase). d-KLA Peptide can be used to carry and deliver genes or small molecules to enhance anti-tumor effects^[1][2].

1523.99

C₇₂H₁₃₈N₂₀O₁₅

286380-05-0

d-{Lys-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Lys}

d-{KLAKLAKKLAKLAK)

NCCCC[C@@H](N)C(N[C@H](CC(C)C)C(N[C@H](C)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](C)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](C)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](C)C(N[C@@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kim H Y, et al. The cell penetrating ability of the proapoptotic peptide, KLAKLAKKLAKLAK fused to the N-terminal protein transduction domain of translationally controlled tumor protein, MIIYRDLISH[J]. Biomaterials, 2011, 32(22): 5262-5268.  [Content Brief]

  [2]. Ko Y T, et al. Cationic liposomes loaded with proapoptotic peptide D-(KLAKLAK) 2 and Bcl-2 antisense oligodeoxynucleotide G3139 for enhanced anticancer therapy[J]. Molecular Pharmaceutics, 2009, 6(3): 971-977.  [Content Brief]