Dabcyl acid sodium  (Synonyms: DABCYL sodium; Para-methyl red sodium)

Dabcyl acid sodium (DABCYL sodium) is a nonfluorescent chromophore and a quencher. Dabcyl acid sodium can be used as molecular beacon nucleic acid probes to recognize and report the presence of specific nucleic acids in homogeneous solutions^[1][2].

Dabcyl acid sodium is paired with fluorophores (such as EDANS) for fluorescence resonance energy transfer (FRET). When the fluorophore (such as EDANS) and Dabcyl acid sodium are close to each other, the fluorescence of the fluorophore will be quenched by Dabcyl acid sodium. When the molecular beacon binds to the target nucleic acid, the fluorophore and the quencher are separated, and the fluorophore emits fluorescence, thereby realizing the detection of the target nucleic acid^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

291.28

C₁₅H₁₄N₃NaO₂

845-46-5

O=C(C1=CC=C(C=C1)/N=N/C2=CC=C(N(C)C)C=C2)O[Na]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tyagi S, et al. Molecular beacons: probes that fluoresce upon hybridization. Nat Biotechnol. 1996 Mar;14(3):303-8.  [Content Brief]

  [2]. Conlon P, et al. Pyrene excimer signaling molecular beacons for probing nucleic acids. J Am Chem Soc. 2008 Jan 9;130(1):336-42.  [Content Brief]