2. Metabolic Enzyme/Protease
  3. Thrombin
  4. Dabigatran-d3

Dabigatran-d3  (Synonyms: BIBR 953-d3; BIBR 953ZW-d3)

Cat. No.: HY-10163S1 Purity: 95.14%
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Dabigatran-d3 is the deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].

For research use only. We do not sell to patients.

Dabigatran-d<sub>3</sub> Chemical Structure

Dabigatran-d3 Chemical Structure

CAS No. : 1246817-44-6

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500 μg USD 220 In-stock
1 mg USD 380 In-stock
5 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Dabigatran-d3:

Dabigatran-d3 Related Antibodies

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Description

Dabigatran-d3 is the deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dabigatran-d3 Related Antibodies
Molecular Weight

474.53

Formula

C25H22D3N7O3
CAS No.
Unlabeled CAS

211914-51-1
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC(CCN(C1=CC=CC=N1)C(C2=CC=C(C(N=C3CNC4=CC=C(C=C4)C(N)=N)=C2)N3C([2H])([2H])[2H])=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

0.1 M HCL : 12.5 mg/mL (26.34 mM; Need ultrasonic)

0.1 M HCL : 12.5 mg/mL (26.34 mM; Need ultrasonic)

DMSO : 10 mg/mL (21.07 mM; ultrasonic and warming and adjust pH to 3 with 1 M HCL and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1073 mL 10.5367 mL 21.0735 mL
5 mM 0.4215 mL 2.1073 mL 4.2147 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 0.1 M HCL / 0.1 M HCL 1 mM 2.1073 mL 10.5367 mL 21.0735 mL 52.6837 mL
5 mM 0.4215 mL 2.1073 mL 4.2147 mL 10.5367 mL
10 mM 0.2107 mL 1.0537 mL 2.1073 mL 5.2684 mL
15 mM 0.1405 mL 0.7024 mL 1.4049 mL 3.5122 mL
20 mM 0.1054 mL 0.5268 mL 1.0537 mL 2.6342 mL
0.1 M HCL / 0.1 M HCL 25 mM 0.0843 mL 0.4215 mL 0.8429 mL 2.1073 mL
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Dabigatran-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dabigatran-d31246817-44-6BIBR 953-d3BIBR 953ZW-d3ThrombinInhibitorinhibitorinhibit

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