Dabigatran etexilate-d₁₃

Name: Dabigatran etexilate-d 13
Brand: MedChemExpress
SKU: HY-10274S
Rating: 4.5 (1 reviews)

Cat. No.: HY-10274S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Dabigatran etexilate-d₁₃ is the deuterium labeled Dabigatran etexilate. Dabigatran etexilate (BIBR 1048) is an orally active proagent of Dabigatran. Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation[1].

For research use only. We do not sell to patients.

Dabigatran etexilate-d<sub>13</sub> Chemical Structure

Dabigatran etexilate-d₁₃ Chemical Structure

CAS No. : 2749293-92-1

Size	Price	Stock	Quantity
1 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Dabigatran etexilate-d₁₃:

Dabigatran etexilate In-stock

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Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

640.81

Formula

C₃₄H₂₈D₁₃N₇O₅

CAS No.

2749293-92-1

Unlabeled CAS

211915-06-9

Appearance

Solid

Color

White to off-white

SMILES

CN1C2=CC=C(C(N(C3=CC=CC=N3)CCC(OCC)=O)=O)C=C2N=C1CNC4=CC=C(C=C4)C(NC(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (156.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5605 mL	7.8026 mL	15.6052 mL
5 mM	0.3121 mL	1.5605 mL	3.1210 mL
10 mM	0.1561 mL	0.7803 mL	1.5605 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Wienen W, et al. In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally activeprodrug, dabigatran etexilate. Thromb Haemost. 2007 Jul;98(1):155-62. [Content Brief]

[3]. Blair HA, Keating GM. Dabigatran Etexilate: A Review in Nonvalvular Atrial Fibrillation. Drugs. 2017;77(3):331-344. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5605 mL	7.8026 mL	15.6052 mL	39.0131 mL
	5 mM	0.3121 mL	1.5605 mL	3.1210 mL	7.8026 mL
	10 mM	0.1561 mL	0.7803 mL	1.5605 mL	3.9013 mL
	15 mM	0.1040 mL	0.5202 mL	1.0403 mL	2.6009 mL
	20 mM	0.0780 mL	0.3901 mL	0.7803 mL	1.9507 mL
	25 mM	0.0624 mL	0.3121 mL	0.6242 mL	1.5605 mL
	30 mM	0.0520 mL	0.2601 mL	0.5202 mL	1.3004 mL
	40 mM	0.0390 mL	0.1951 mL	0.3901 mL	0.9753 mL
	50 mM	0.0312 mL	0.1561 mL	0.3121 mL	0.7803 mL
	60 mM	0.0260 mL	0.1300 mL	0.2601 mL	0.6502 mL
	80 mM	0.0195 mL	0.0975 mL	0.1951 mL	0.4877 mL
	100 mM	0.0156 mL	0.0780 mL	0.1561 mL	0.3901 mL