2. Peptides
  3. Peptide and Derivatives
  4. Peptides for Drug Delivery
  5. Targeting Peptides
  6. DAG peptide

DAG peptide is a cyclic peptide. DAG peptide selectively recognizes a subset of astrocytes that are activated in Alzheimer's disease (AD) starting at an early stage of the disease. DAG peptide can be used as a tool to enhance the delivery of therapeutics and imaging agents to sites of vascular changes and astrogliosis in diseases associated with neuroinflammation.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

DAG peptide Chemical Structure

DAG peptide Chemical Structure

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Based on 1 publication(s) in Google Scholar

DAG peptide Related Antibodies

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Description

DAG peptide is a cyclic peptide. DAG peptide selectively recognizes a subset of astrocytes that are activated in Alzheimer's disease (AD) starting at an early stage of the disease. DAG peptide can be used as a tool to enhance the delivery of therapeutics and imaging agents to sites of vascular changes and astrogliosis in diseases associated with neuroinflammation[1].

Molecular Weight

1006.16

Formula

C38H67N15O13S2
Appearance

Solid

Color

White to off-white

Sequence

Cys-Asp-Ala-Gly-Arg-Lys-Gln-Lys-Cys (disulfide bridge: Cys1-Cys9)
Sequence Shortening

CDAGRKQKC (disulfide bridge: Cys1-Cys9)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (99.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9939 mL 4.9694 mL 9.9388 mL
5 mM 0.1988 mL 0.9939 mL 1.9878 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.61%

SDS (252 KB)

COA (261 KB) RP-HPLC (272 KB) MS (68 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9939 mL 4.9694 mL 9.9388 mL 24.8469 mL
5 mM 0.1988 mL 0.9939 mL 1.9878 mL 4.9694 mL
10 mM 0.0994 mL 0.4969 mL 0.9939 mL 2.4847 mL
15 mM 0.0663 mL 0.3313 mL 0.6626 mL 1.6565 mL
20 mM 0.0497 mL 0.2485 mL 0.4969 mL 1.2423 mL
25 mM 0.0398 mL 0.1988 mL 0.3976 mL 0.9939 mL
30 mM 0.0331 mL 0.1656 mL 0.3313 mL 0.8282 mL
40 mM 0.0248 mL 0.1242 mL 0.2485 mL 0.6212 mL
50 mM 0.0199 mL 0.0994 mL 0.1988 mL 0.4969 mL
60 mM 0.0166 mL 0.0828 mL 0.1656 mL 0.4141 mL
80 mM 0.0124 mL 0.0621 mL 0.1242 mL 0.3106 mL
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DAG peptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DAG peptideOthersAlzheimer's diseasecyclic peptideastrocytesInhibitorinhibitorinhibit

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