2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Dalargin

Dalargin is a potent δ-opioid receptor agonist. Dalargin mitigates Gentamicin (HY-A0276)-induced cell death. Dalargin shows nephroprotective effects on Gentamicin-induced kidney injury. Dalargin shows antiulcer activity.

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Dalargin Chemical Structure

Dalargin Chemical Structure

CAS No. : 81733-79-1

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Based on 1 publication(s) in Google Scholar

Dalargin Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dalargin is a potent δ-opioid receptor agonist. Dalargin mitigates Gentamicin (HY-A0276)-induced cell death. Dalargin shows nephroprotective effects on Gentamicin-induced kidney injury. Dalargin shows antiulcer activity[1][2][3].

IC50 & Target[2]

δ Opioid Receptor/DOR

 

In Vitro

Dalargin (100 µg/mL; 1 h) mitigates gentamicin-induced cell death of renal epithelium in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dalargin Related Antibodies

Cell Viability Assay[2]

Cell Line: Kidney cells
Concentration: 100 µg/mL
Incubation Time: 1 h (prior to treatment with 1.2–2.5 mg/ml gentamicin for 24 h)
Result: Reduced kidney cells death.
In Vivo

Dalargin (25, 50 µg/kg; i.p.) shows nephroprotective effects on gentamicin-induced kidney injury in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 290-350 g, White male rats[2]
Dosage: 25, 50 µg/kg
Administration: I.p. (3 h before each gentamicin injection)
Result: Mitigated gentamicin-induced acutekidney injury, attenuated ROS generation and oxidative stress, alleviated histopathological changes in a renal tissue.
Molecular Weight

725.83

Formula

C35H51N9O8
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

YAGFLR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (137.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3777 mL 6.8887 mL 13.7773 mL
5 mM 0.2755 mL 1.3777 mL 2.7555 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3777 mL 6.8887 mL 13.7773 mL 34.4433 mL
5 mM 0.2755 mL 1.3777 mL 2.7555 mL 6.8887 mL
10 mM 0.1378 mL 0.6889 mL 1.3777 mL 3.4443 mL
15 mM 0.0918 mL 0.4592 mL 0.9185 mL 2.2962 mL
20 mM 0.0689 mL 0.3444 mL 0.6889 mL 1.7222 mL
25 mM 0.0551 mL 0.2755 mL 0.5511 mL 1.3777 mL
30 mM 0.0459 mL 0.2296 mL 0.4592 mL 1.1481 mL
40 mM 0.0344 mL 0.1722 mL 0.3444 mL 0.8611 mL
50 mM 0.0276 mL 0.1378 mL 0.2755 mL 0.6889 mL
60 mM 0.0230 mL 0.1148 mL 0.2296 mL 0.5741 mL
80 mM 0.0172 mL 0.0861 mL 0.1722 mL 0.4305 mL
100 mM 0.0138 mL 0.0689 mL 0.1378 mL 0.3444 mL
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Dalargin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dalargin81733-79-1Opioid ReceptorInhibitorinhibitorinhibit

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