2. Inhibitory Antibodies
  3. Dargistotug

Dargistotug  (Synonyms: M-6223)

Cat. No.: HY-P990031

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Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting TIGIT (T cell immune receptor with Ig domain and ITIM). TIGIT is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function.

For research use only. We do not sell to patients.

CAS No. : 2649362-29-6

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1 mg USD 350 In-stock
5 mg USD 910 In-stock
10 mg USD 1450 In-stock
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Description

Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting TIGIT (T cell immune receptor with Ig domain and ITIM). TIGIT is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Dargistotug]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Dargistotug Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dargistotug2649362-29-6M-6223M6223M 6223OthersInhibitorinhibitorinhibit

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